PerkinElmer Company Overview
At PerkinElmer we're taking action to improve the health and safety of people and the environment. We're committed to transforming risk into safety, mystery into knowledge and ideas into action for healthier today and even better tomorrow. We are committed to delivering solutions that improve our customers' outcomes, advance human and environmental health technologies and, deliver shareholder value. Every day, we work together to ensure the way we do business is as meaningful as the solutions we provide.
PKI Mantra Intro 2015
The Mantra™ quantitative pathology workstation lets you visualize, quantify, and phenotype multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research. Mantra allows you to maintain tissue morphology to help better understand the types and roles of cells within the tumor and tumor microenvironment. The system comes with powerful inForm® Tissue Finder™ advanced image analysis software that features user-trainable algorithms for automatic recognition of specific tissue and cell types, as well as per-cell analysis of biomarker expression and phenotyping to differentiate among cell types. Pathology Views™ creates familiar-looking brightfield (H&E, DAB, hematoxylin) renderings from original multi-label fluorescence images. PerkinElmer’s cancer immunology workflow has been validated using Opal™ reagent kits. Opal methodology enables specific staining of multiple tissue biomarkers reaching up to 6-plex and beyond in a single tissue section. Learn more: http://www.perkinelmer.com/catalog/pr...
Together we can help Revolutionizing Medicine
Together we can help Revolutionizing Medicine
Metalloproteins and Medicine
如何采取快照？为什么拍快照？我们的快照的酶的人群、核糖核酸还原酶、活性部位自由基的产生、变构调节、RNRs是重要的药物靶点；抗肿瘤、抗寄生虫和抗病毒治疗，在此一一为您讲解。
Metalloproteins and the Environment
B12定位在CH3转移cfesp如何？摆动夹紧动作B12 17 Å.复杂我们守在这里 。你为什么需要140（或220）为转移甲基？在一部分，以形成一个稳定的框架，以允许这些大；构象变化是催化的关键。
The role of ATP binding and hydrolysis at GroEL
领略过在真核细胞中的伴侣蛋白分子及伴侣辅助蛋白质折叠的你是否想进一步了解什么是ATP？当绑定是必要的，什么时候是水解需要？在此 Art Horwich娓娓道来在这两个工作中都有两种结合：顺式和反式环 ，顺：约束力GroES，激活折叠rxn ；在反式：触发弹出，如果顺式配体；酶水解进步机，顺解门配体进入反式环 。
Assembly-Line Biosynthesis of Polyketide antibiotics:Part 1
Chaitan Khosla从进化生物学、化学、结构研究装配线polyketid抗生素生物合成，介绍装配线的机制，分析一个模块的SAXS和连续两模块SAXS。
Assembly-Line Biosynthesis of Polyketide antibiotics:Part2
从装配线酶的工具和特异性研究体内的重构，纯化的蛋白质的装配线重建。讲解核心反应分析、 定向性、下游延伸单位的特异性酶、装配线的扩展单元的特异性、反式互补的高活性酶。
Synthetic Biology & Metabolic Engineering Teaching an Old Bacterium New Tricks
在第一部分，普莱瑟博士解释说，合成生物学涉及工程原理应用到生物的系统建立生物机器。在建筑这些机器的关键材料是合成DNA。合成DNA可以添加在不同的组合，以生物宿主，如细菌，把它们变成化学工厂，能生产小分子的选择。
Synthetic Biology & Metabolic Engineering Teaching an Old Bacterium New Tricks
在2部分，普拉瑟介绍了她的实验室使用的设计原则设计E. coli从葡萄糖生产葡萄糖二酸。葡糖酸不在细菌中自然产生的所以，普拉瑟和她的同事们“bioprospected”从其他生物酶并在大肠杆菌中表达，构建所需的酶途径。普拉瑟走我们通过优化时序的许多步骤，酶表达的定位和水平，以产生最大的产量。