Regenerative medicine for brain and nerve repair

We isolated and propagated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell therapy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenerative medicine of brain and optic nerve injury.

sRNA Induces the Large-scale Transdetermination of Mesenchymal Stem Cells into Hematopoietic Stem Cells in Human.

Mesenchymal stem cells (MSCs) can differentiate into cells of bone, endothelium, adipose tissue, cartilage, muscle, and brain. However, whether they can transdeterminate into hematopoietic stem cells (HSCs) remains unsolved. We report here that a subpopulation of human MSCs that are CD44+,CD29+, CD105+, CD166+,CD133-,CD34- could differentiate into hematopoietic stem cells (CD150+/CD133+/CD34+) and their descending blood cells in vitro, when transfected with new endogenous shRNAs The sRNA was high-effectively delivered into MSCs by a novel peptide means. These induced MSC-HSCs could form different types of hematopoietic colonies as nature-occurring HSCs did. Upon transplantation into sublethally irradiated NOD/SCID mice, these MSC-HSCs engrafted and differentiated into all hematopoietic lineages such as erythrocytes, lymphocytes, myelocytes and thrombocyte. More importantly, these induced HSCs could successfully engraft and effectively function in patients with severe aplastic anemia. Furthermore, we demonstrated the first evidence that the transdetermination of MSCs was induced by acetylation of histone proteins and activation of many transcriptional factors. Together, our findings identify the sRNAs that dictates a directed differentiation of MSCs toward HSCs and open up a new source for HSCs used for the treatment of blood diseases and artificial stem cell-made blood.

基于android系统的远程人体生理参数检测系统

其远程生理参数检测仪在2012年12月获得SFDA注册，是一款带有RFID身份识别功能，用于对人体血压、血糖、血氧、脉搏检测，并可录入体温、身高与体重（自动计算BMI指数）等生理参数，并通过GPRS网络与健康信息分析系统进行数据通信，并可配套手机APP进行用户数据绑定及查询的产品。

目前已上市一年多，已销售2500余台，该产品销售额超过500万。

immunotherapy against cancers(position of sellular therapy)

Regenerative medicine for brain and nerve repair

We isolated and propagated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell therapy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenerative medicine of brain and optic nerve injury.

PTMScan®蛋白翻译后修饰技术简介

利用Cell Signaling Technology (CST)公司开发的针对蛋白质翻译后修饰(PTM)基序(motif)抗体, 在肽段水平上免疫亲和富集带有不同PTM的肽段,利用液相色谱-串联质谱(LC-MS/MS)进行定量分析,能够快速、准确、高通量地分析多种疾病相关信号通路关键节点蛋白磷酸化、乙酰化、甲基化和 泛素化修饰的变化,满足创新性研究、生物标志物鉴定、药物靶点筛选和评价的需求。

Stefan Larsson:医生们可以互相学习

不同医院的不同手术有着不同的结果。但是病人不知道数据, 所以使得选外科医生成为了一个高风险的猜测游戏。

史帝芬·拉森（Stefan Larsson）研究了当医生开始衡量并分享他们的髋关节手术的结果时（比如说什么是最有效的方法）会发生的情况。

如果医生们可以相互学习并形成一个反馈循环，医疗保健会不会变得更好、更便宜？

Alan Russell:讲人体的再生

Alan Russell研究的是再生医学 - 以一种突破性的思维方式去看待疾病与损伤，以一种方式向人体发送信号诱导其进行自我修复。

andres Lozano帕金森氏综合症、抑郁症和关闭它们的开关

大脑深部电击术变得相当精准。借由这项科技，外科医生几乎能将电极置入大脑的任何区域,像电台或恒温器的调节旋钮一项,增强或减弱回路信号。一位罹患帕金森氏综合症的妇女，在电击后立即停止肢体抖动，以及老年痴呆症患者脑部功能恢复，我们看到这项科技带来的巨大改变。

Interplays between Mesenchymal Stem Cells and Immune Responses

Mesenchymal stem cells (MSCs) exist in almost all tissues and are crucial in maintaining the cellular homeostasis of multicellular organisms. They provide the ultimate cell source for tissue repair and regeneration. Under pathological conditions, these cells are awakened, activated, and mobilized to damaged tissue sites. Since tissue damages are often accompanied by inflammatory factors, from both innate immune response and adaptive immune response, it is sensible that MSCs delicately interact with inflammatory factors at the sites of tissue damages.

Depending on the type and persistence of the inflammatory factors, the activated MSCs could lead either to complete or partial tissue repair, or to chronic inflammation and further tissue damage, such as cancer and fibrosis. Indeed, recent studies have shown that there is a bidirectional interaction between MSCs and inflammatory cells and cytokines. However, much information of this information remains to be elucidated. Further investigations in this newly emerging exciting research area will undoubtedly lead to better understanding of pathogenesis of various diseases and novel treatment strategies.