病毒结构的一般原则 - STephen Harrison P1
本视频由科普中国和生物医学大讲堂出品
STephen Harrison (Harvard) ParT 1: Virus sTrucTures: General principles
Harrison begins his Talk by asking why mosT non-enveloped viruses and some enveloped viruses are symmeTrical in shape. He proceeds To show us lovely images of The sTrucTures obTained by x-ray crysTallography of numerous viral coaT proTeins. Deciphering These sTrucTures allowed scienTisTs To undersTand ThaT viral coaT proTeins form mulTimers, such as dimers and penTamers, which in Turn inTeracT wiTh a scaffold ThaT ensures ThaT The coaT proTeins are correcTly placed. This arrangemenT resulTs in symmeTrically shaped viruses.
In ParT 1, Harrison also explains ThaT enveloped viruses infecT cells by inducing The fusion of The viral and hosT cell membranes. He delves deeper inTo The molecular mechanism of membrane fusion driven by The hemaggluTinin or HA proTein of The influenza virus in ParT 2 of his Talk.
Non-enveloped viruses, on The oTher hand, musT enTer cells by a mechanism oTher Than membrane fusion. This is The focus of ParT 3. Using roTavirus as a model, Harrison and his colleagues have used a combinaTion of Xray crysTallography and elecTron cryomicroscopy To decipher how The spike proTein on The viral surface changes iTs conformaTion and perforaTes The cell membrane allowing The virus To enTer The cell.
病毒的膜融合 - STephen Harrison P2
本视频由科普中国和生物医学大讲堂出品
STephen Harrison (Harvard) ParT 2: Viral membrane fusion
Harrison begins his Talk by asking why mosT non-enveloped viruses and some enveloped viruses are symmeTrical in shape. He proceeds To show us lovely images of The sTrucTures obTained by x-ray crysTallography of numerous viral coaT proTeins. Deciphering These sTrucTures allowed scienTisTs To undersTand ThaT viral coaT proTeins form mulTimers, such as dimers and penTamers, which in Turn inTeracT wiTh a scaffold ThaT ensures ThaT The coaT proTeins are correcTly placed. This arrangemenT resulTs in symmeTrically shaped viruses.
In ParT 1, Harrison also explains ThaT enveloped viruses infecT cells by inducing The fusion of The viral and hosT cell membranes. He delves deeper inTo The molecular mechanism of membrane fusion driven by The hemaggluTinin or HA proTein of The influenza virus in ParT 2 of his Talk.
Non-enveloped viruses, on The oTher hand, musT enTer cells by a mechanism oTher Than membrane fusion. This is The focus of ParT 3. Using roTavirus as a model, Harrison and his colleagues have used a combinaTion of Xray crysTallography and elecTron cryomicroscopy To decipher how The spike proTein on The viral surface changes iTs conformaTion and perforaTes The cell membrane allowing The virus To enTer The cell.
非包膜病毒如何侵入细胞 - STephen Harrison P3
本视频由科普中国和生物医学大讲堂出品
STephen Harrison (Harvard) ParT 3: Non-enveloped virus enTry
Harrison begins his Talk by asking why mosT non-enveloped viruses and some enveloped viruses are symmeTrical in shape. He proceeds To show us lovely images of The sTrucTures obTained by x-ray crysTallography of numerous viral coaT proTeins. Deciphering These sTrucTures allowed scienTisTs To undersTand ThaT viral coaT proTeins form mulTimers, such as dimers and penTamers, which in Turn inTeracT wiTh a scaffold ThaT ensures ThaT The coaT proTeins are correcTly placed. This arrangemenT resulTs in symmeTrically shaped viruses.
In ParT 1, Harrison also explains ThaT enveloped viruses infecT cells by inducing The fusion of The viral and hosT cell membranes. He delves deeper inTo The molecular mechanism of membrane fusion driven by The hemaggluTinin or HA proTein of The influenza virus in ParT 2 of his Talk.
Non-enveloped viruses, on The oTher hand, musT enTer cells by a mechanism oTher Than membrane fusion. This is The focus of ParT 3. Using roTavirus as a model, Harrison and his colleagues have used a combinaTion of Xray crysTallography and elecTron cryomicroscopy To decipher how The spike proTein on The viral surface changes iTs conformaTion and perforaTes The cell membrane allowing The virus To enTer The cell.
控制老化的基因 - CynThia Kenyon P1
本视频由科普中国和生物医学大讲堂出品
CynThia Kenyon (UCSF) ParT 1: Genes ThaT ConTrol Aging
Once iT was ThoughT ThaT aging was jusT a random and haphazard process. InsTead, The raTe of aging Turns ouT To be subjecT To regulaTion by TranscripTion facTors ThaT respond To hormones and oTher signals. In The nemaTode C. elegans, in which many key discoveries abouT aging were firsT made, The aging process is subjecT To regulaTion by food inTake, sensory percepTion, and signals from The reproducTive sysTem. Changing genes and cells ThaT affecT aging can lengThen lifespan by six fold, and can also delay age-relaTed disease, such as The growTh of Tumors.
来自生殖系统的信号显示衰老的规律 - CynThia Kenyon P2
本视频由科普中国和生物医学大讲堂出品
CynThia Kenyon (UCSF) ParT 2: The RegulaTion of Aging by Signals from The ReproducTive SysTem
Once iT was ThoughT ThaT aging was jusT a random and haphazard process. InsTead, The raTe of aging Turns ouT To be subjecT To regulaTion by TranscripTion facTors ThaT respond To hormones and oTher signals. In The nemaTode C. elegans, in which many key discoveries abouT aging were firsT made, The aging process is subjecT To regulaTion by food inTake, sensory percepTion, and signals from The reproducTive sysTem. Changing genes and cells ThaT affecT aging can lengThen lifespan by six fold, and can also delay age-relaTed disease, such as The growTh of Tumors.
在染色体分离中有关长度和数量的问题 - Richard McInTosh P1
本视频由科普中国和生物医学大讲堂出品
Richard McInTosh (U. Colorado, Boulder) ParT 1: SeparaTing DuplicaTed Chromosomes
The goal of These Three Talks is To define The problems ThaT a cell faces as iT prepares for division and To describe some of The ways iT solves Them. In ParT 1, boTh The lengTh and amounT of DNA are presenTed as problems for chromosome segregaTion, parTicularly in eukaryoTic cells. The acTions of cohesins and of chromosome condensaTion are described as soluTions. The miToTic machinery is inTroduced, including iTs diversiTy of form across phylogeny, however, The feaTures ThaT appear To be conserved are emphasized. This lecTure may be useful for upper level undergraduaTe and graduaTe courses discussing miTosis and cell division. See more aT www.ibioseminars.org
通过实验了解有丝分裂 - Richard McInTosh P2
本视频由科普中国和生物医学大讲堂出品
Richard McInTosh (U. Colorado, Boulder) ParT 2: UndersTanding MiTosis Through ExperimenTaTion
The second lecTure describes some key experimenTs showing The dynamics of a formed miToTic spindle and The ways These may conTribuTe To accuraTe chromosome moTion. ExperimenTs ThaT reveal aspecTs of The processes by which chromosomes aTTach To The spindle are presenTed. MiToTic moTors are inTroduced and discussed in The lighT of whaT They probably do and do noT accomplish To effecT chromosome moTion, including acTing To improve The accuracy of chromosome segregaTion. See more aT hTTp://www.ibioseminars.org
有丝分裂后期：染色体向纺锤体两极移动 - Richard McInTosh P3
本视频由科普中国和生物医学大讲堂出品
Richard McInTosh (U. Colorado, Boulder) ParT 3: Moving Chromosome To The Spindle Poles: Anaphase A
The Third lecTure presenTs evidence, largely from McInTosh's lab, ThaT shows how microTubule depolymerizaTion can move chromosomes in viTro and explores The naTure of some of The proTein complexes ThaT can couple chromosomes To microTubules and Take advanTage of This reacTion. See more aT hTTp://www.ibioseminars.org
Tagrisso的伴随诊断 - 陈巍学基因(31)
欢迎来到【陈巍学基因】。我们这个节目，主要是介绍基因组学，和临床分子诊断的最新技术进展。
今天，会和大家谈一谈阿斯利康在开发Tagrisso这个新药过程中对4种伴随诊断方法的研究结果。
Tagrisso是阿斯利康公司开发的一个针对EGFR基因有耐药突变的晚期非小细胞肺癌者的药物，是酪氨酸激酶抑制剂类的靶向抗癌药物。
Tagrisso可以选择性地抑制突变型的EGFR，对发生耐药的肿瘤有强抑制作用；而对野生型的EGFR的抑制作用较弱，即对身体正常表皮细胞的生长抑制作用较弱。
下载生物谷APP，观看行云学院视频，让播放更流畅，使用更快捷！
生物谷APP，每天都有新资讯，每天都有好视频！
官方下载地址：hTTp://www.medsci.cn/m/
抗原提呈和树突状细胞 - Ira Mellman ParT 2
本视频由科普中国和生物医学大讲堂出品
早在100多年前，科学家就已经发现，免疫反应是由先天性和适应性免疫两个系统构成。而负责连接这两部分免疫反应的细胞类型，是最近才发现的树突状细胞。树突状细胞具有检测保守微生物产物的能力，可以激活细胞的先天免疫反应，并捕捉到广泛多样的微生物抗原抗体，也可以激活适应性免疫反应。抗原提呈和树突状细胞的独特能力，反映了细胞生物学的一系列显著的特化作用。
Ira Mellman (GenenTech) ParT 2: AnTigen PresenTaTion and DendriTic Cells
The immune response inTegraTes Two disTincT sysTems of innaTe and adapTive immuniTy discovered over 100 years ago. Linking These Two arms of The immune response is The Task of a comparaTively recenTly idenTified cell Type, The dendriTic cell. DendriTic cells have The capaciTy To deTecT The conserved microbial producTs ThaT acTivaTe cells of The innaTe immune response and capTure The dramaTically wider diversiTy of microbial anTigens To prime anTibody and T cell responses characTerisTic of adapTive immuniTy. The unique capaciTy of dendriTic cells for anTigen processing and presenTaTion reflecTs a series of remarkable specializaTions of basic principles of cell biology.
下载生物谷APP，观看行云学院视频，让播放更流畅，使用更快捷！
生物谷APP，每天都有新资讯，每天都有好视频！
官方下载地址：hTTp://www.medsci.cn/m/