我生命中的科学课
Avram Hershko (Technion): Lessons from My Life in Science
Hershko lists lessons that he has learned from a happy and productive life in science. These lessons include, "choose your mentor well" and "have fun". Although Hershko directs his advice to young researchers, established scientists would do well to follow it too.
BioBus的移动科学实验室
Ben Dubin-Thaler & Sarah Weisberg (BioBus): The BioBus Mobile Science Lab
The BioBus is an ecologically friendly, mobile, biology lab that provides children and adults with the chance to experience the excitement of hands-on science. Ben Dubin-Thaler and Sarah Weisberg explain why they chose to create and work on the BioBus and the joy of working with scientists and teachers to develop fun and educational opportunities for all ages.
用CRISPR寻找新肿瘤药 - 陈巍学基因(32)
欢迎来到【陈巍学基因】,我们这个节目,主要是给大家介绍基因组学,和临床分子诊断的最新技术进展。
今天要和大家谈的,是用CRISPR方法,来寻找新的、可能的肿瘤药物。
提出这个方法的,是加拿大Donnelly Centre的Traver Hart。Traver Hart把他的这项研究成果,发表在《Cell》杂志2015年12月3日这一期上。论文的题目是《High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities》。我们这期节目,就主要围绕这篇文章来进行讲解。
文章的核心内容,就是:
1.用CRISPR方法,把几种肿瘤细胞系的几乎所有的基因都做一遍敲除,也就是“Knock out”。
2.然后用高通量测序,来看哪些基因被敲除之后,细胞的生长会受到抑制。
3.接下来,在几种肿瘤细胞系之间进行比较,看哪个基因,是对一个特定细胞系的生长,是必需的,而在别的细胞系当中,这个基因是非必需的。那么,这个基因就可能是治疗这种肿瘤的,潜在的、新的治疗靶点
本视频详细介绍了这种全新的方法,和用这个方法找到的一系列潜在的新药化合物的实例。
用血小板RNA-seq测肿瘤 - 陈巍学基因(33)
Myron G. Best 等人发现,可以用血小板RNA-seq测序结合生物信息学分析,很好地判断: 1、一个人是否患有肿瘤; 2、是患的哪种肿瘤; 3、肿瘤中有哪些突变。 本视频介绍了这项发现的成果、实验方法、分析思路。
白宫科学研究员如何影响政府决策
Dr. Fletcher describes his experience of spending a year in Washington D.C. as a White House Fellow. He discusses the role of science in policymaking and addresses the question of how scientists can be effective in influencing decisions in government.
成功女科学家的故事和策略
Throughout her career, Daniell benefitted from the support of a group of fellow female scientists.
Dr. Daniell is the author of the book “Every Other Thursday. Stories and Strategies from Successful Women Scientists”. Daniell was an Assistant Professor of Molecular Biology at the University of California, Berkeley and worked in the biotechnology industry before deciding to write about her group experience.
驳斥创造论和保护进化论的教学权利
Recognizing and understanding the three main arguments against evolution or the "pillars of creationism", says Scott, will help teachers and scientists to refute creationism and defend the teaching of evolution in public schools.
科学家如何利用维基百科
Schulenburg outlines three main reasons why scientists should contribute to Wikipedia; you will learn a lot from the feedback of editors and readers, it is a chance to give back to the Wikipedia community, and your writing will have a much larger audience than in most traditional journals.
鼓励学生对科学的好奇心
The opportunity to engage in research as an undergraduate student was pivotal in Hatfull's decision to pursue a career in science. This experience convinced Hatfull and his colleagues to set up a program that allows undergraduates and high school students, to participate in isolating bacteriaphage. Hatfull makes a case for allowing all curious students to engage in authentic research.
非洲大学的重建
Dr. Debas is the Director of the UC Global Health Institute and the Senior Global Health Advisor at UCSF. He was the founding Executive Director of UCSF Global Health Sciences which was established in 2003. Prior to that, he held several positions at UCSF including Chancellor and Dean of the School of Medicine.