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sRNA InduCES the Large-scale Transdetermination of Mesenchymal Stem Cells into Hematopoietic Stem Cells in Human.

Mesenchymal stem cells (MSCs) can differentiate into cells of bone, endothelium, adipose tissue, cartilage, muscle, and brain. However, whether they can transdeterminate into hematopoietic stem cells (HSCs) remains unsolved. We report here that a subpopulation of human MSCs that are CD44+,CD29+, CD105+, CD166+,CD133-,CD34- could differentiate into hematopoietic stem cells (CD150+/CD133+/CD34+) and their descending blood cells in vitro, when transfected with new endogenous shRNAs The sRNA was high-effectively delivered into MSCs by a novel peptide means. These induced MSC-HSCs could form different types of hematopoietic colonies as nature-occurring HSCs did. Upon transplantation into sublethally irradiated NOD/SCID mice, these MSC-HSCs engrafted and differentiated into all hematopoietic lineages such as erythrocytes, lymphocytes, myelocytes and thrombocyte. More importantly, these induced HSCs could sucCESsfully engraft and effectively function in patients with severe aplastic anemia. Furthermore, we demonstrated the first evidence that the transdetermination of MSCs was induced by acetylation of histone proteins and activation of many transcriptional factors. Together, our findings identify the sRNAs that dictates a directed differentiation of MSCs toward HSCs and open up a new source for HSCs used for the treatment of blood diseases and artificial stem cell-made blood.

2014-09-26 课时:36分钟

JSR Life ScienCES诊断试剂原料

诊断试剂原料类产品包括:诊断试剂用原料(乳胶微球、磁性粒子、封闭剂)、研究用材料试剂(超常磁珠、粒子和功能配体)、和标准离子。主要用于诊断试剂的研发与生产、蛋白质与核酸的分离、微粒子计数器的校正等。

2014-12-07 课时:5分钟

JSR Life ScienCES业务介绍

捷时雅(上海)商贸有限公司是JSR 集团在中国的全资子公司,其生物技术部全面负责JSR Life ScienCES公司及其控股子公司的生物工艺器材、诊断试剂原料和医用高分子材料等产品在中国的市场推广、销售和技术支持工作。生物工艺器材类产品包括:亲和层析填料(protein A 亲和填料)、离子交换层析膜(NatriFlo HD-Q)、三维细胞培养耗材及试剂(SCIVAX)等,主要用于新药候选物筛选、药物毒性评估、生物医药工业的下游分离和纯化及大规模制备生产等领域;

2014-12-10 课时:4分钟

JSR Life ScienCES生物工艺器材

JSR Life ScienCES给中国的抗体药物研发及生产单位,提供一套独有的下游工艺解决方案。

Amspere JWT203 Protein A 填料用于抗体药物的捕获,NatriFlo HD-Q 离子交换膜用于抗体药物精细 纯化步骤,有效降低用户的生产成本,缩短工艺时间,提高工艺的稳定性。ChromaCon 的连续层析系统为抗体药物的质控分析提供高精度高分辨率的工具,有效分离和分析抗体酸碱变体。

2014-12-23 课时:5分钟

Photoreceptors and Image ProCESsing Part 1A - Jeremy Nathans

本视频由科普中国和生物医学大讲堂出品

Jeremy Nathans (Johns Hopkins) Part 1A: Photoreceptors and Image ProCESsing

In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org

2016-01-08 课时:36分钟

Photoreceptors and Image ProCESsing Part 1B - Jeremy Nathans

本视频由科普中国和生物医学大讲堂出品

Jeremy Nathans (Johns Hopkins) Part 1B: Photoreceptors and Image ProCESsing

In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org

2016-01-08 课时:34分钟