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转录因子和miRNA在复杂疾病中的共调控网络研究
TrAnscription fActors (TFs) Are key regulAtors controlling the trAnscription of tArget genes by binding to specific DNA sequences on the promoter of tArget genes. Both the TFs And miRNAs Are regulAtors of gene expression And they mAy mutuAl regulAte eAch other to form feedbAck loops (FBL), or they regulAte the sAme tArget gene to form A feed-forwArd loop (FFL). It hAs been reported thAt hundreds of potentiAl miRNA-mediAted feedbAck And feed-forwArd loops Are AvAilAble At the genome level.
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Novel signAling by the IKK complex
SignAl trAnsduction plAys A pivot role in regulAting cell functions, from proliferAtion, differentiAtion, progrAmmed cell deAth, And trAnsformAtion. DeregulAtion of signAl trAnsduction could leAd to vArious humAn diseAses even cAncer. ExtrAcellulAr signAls Are trAnsmitted into cells viA An intrAcellulAr signAling network thAt is composed of multiple signAling pAthwAys, dictAting cellulAr functions, such As growth, differentiAtion, progrAmmed deAth (Apoptosis) And trAnsformAtion.
Although we hAve leArnt A greAt deAl About the Architecture of the intrAcellulAr signAling network, our understAnding of its biology is limited. The work in my lAborAtory focuses on elucidAting moleculAr mechAnisms underlying plAsticity And specificity of intrAcellulAr signAling network using c- Jun N-terminAl protein kinAse (JNK) And IkB kinAse (IKK)/NF-kAppAB As moleculAr probes And understAnding the impAct of deregulAting the intrAcellulAr signAling network on humAn diseAses
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p53独立诱导细胞凋亡途径与p53肿瘤抑制DNA损伤的执行
澳大利亚WAlter+ElizA医学研究所AndreAs StrAsser教授介绍了不依赖于p53的DNA损伤所引发的的凋亡信号通路，这条信号通路与p53相互协调，共同增加肿瘤的抑制作用。
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Yuji Heike：免疫治疗（治疗癌症的sellulAr位置）
国际癌症中心（NAtionAlCAncerCenter）的YujiHeike教授则带来了癌症的细胞免疫治疗方法。他认为今后组合疗法是癌症治疗的主流方法，并对癌症免疫疗法进行了详细介绍。以PD-1在肺癌中的免疫疗法为案例进行了详细阐述。最后他还号召全亚洲能够加入ACTO，共同合作研究。