AJE:女性服鳕鱼肝油会增骨折风险
长期以来，鳕鱼肝油一直是补充维生素D的一大来源。近日，《美国流行病学杂志》（AJE）刊登的挪威一项新研究发现，鳕鱼肝油会带来始料不及的后果——降低骨密度。
研究人员发现，在3000多名受访中年妇女中，儿时服用鳕鱼肝油的人的骨密度要低于不服用鱼肝油的妇女。
新研究负责人挪威科技大学教授西莉·福斯摩博士表示，鳕鱼肝油中所含的大量维生素A可能是导致骨密度降低副作用的关键。一旦人体脂肪中维生素A积累过量，就会对骨质新陈代谢产生负面影响，实际上增加骨折的危险。（来源：人民网-健康时报 徐澄编译）
生物谷推荐原始出处：
（AJE），2008 167(4):406-411，Siri Forsmo，Arnulf Langhammer
Childhood Cod Liver Oil Consumption and Bone Mineral Density in a Population-based Cohort of Peri- and Postmenopausal Women
Siri Forsmo, Sigurd Kjorstad Fjeldbo and Arnulf Langhammer
Use of cod liver oil, which is rich in vitamins A and D, is traditionally recommended during the fall and winter months as a protective measure against vitamin D deficiency in several countries. It is not known whether childhood cod liver oil intake is related to variations in bone mineral density (BMD) or fractures in adult life. In 2001, a total of 3,052 Norway women aged 50–70 years had forearm BMD measured in a substudy of the population-based Nord-Tr?ndelag Health Study. Women reporting no childhood cod liver oil intake had statistically significantly higher BMD than those with any ingestion of cod liver oil. The odds ratio for low BMD (>1 standard deviation below age-specific mean) in women reporting cod liver oil intake throughout the year as compared with women with no intake was 2.3 (95% confidence interval: 1.4, 3.9), adjusted for body mass index, smoking, menopausal status, estrogen use, and current milk consumption. There were indications of a negative dose-response effect of childhood cod liver oil intake on bone. Although the vitamin A content of commercial cod liver oil was recently reduced by 75% in Norway, the past high concentration remains a possible explanation for the observed negative association between childhood cod liver oil intake and forearm BMD.
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