Emerging Molecular Concepts in Oncology
An AACR Special Conference in Cancer Research
Sponsored by Merck Research Laboratories
October 24 – 26, 2006
Ruijin Hospital Auditorium
Shanghai
An intensive and interactive 3-day workshop on the latest developments in molecular cancer biology for predoctoral students, postdoctoral fellows and junior faculty members in basic and clinical cancer research.
Conference chairpersons:
Stephen H. Friend, Merck Research Laboratories, Upper Gwynedd, PA, USA
Charles L. Sawyers, HHMI, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Zhu Chen, Chinese Academy of Sciences, Beijing, China
Zhenggang Zhu, School of Medicine, Jiaotong University, Shanghai, China
Confirmed speakers:
Stephen B. Baylin, Johns Hopkins University, Baltimore, MD, USA
René Bernards, The Netherlands Cancer Institute, Amsterdam, The Netherlands
James M. Roberts, HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
William G. Kaelin, Jr., HHMI, Dana-Farber Cancer Institute, Boston, MA, USA
Alan D. D'Andrea, Dana-Farber Cancer Institute, Boston, MA, USA
James R. Downing, St. Jude Children's Research Center, Memphis, TN, USA
Paul Workman, Cancer Research UK, Sutton, England
Qimin Zhan, Chinese Academy of Medical Sciences, Beijing, China
Jianren Gu, Shanghai Cancer Institute, Shanghai, China
Edison T. Liu, Genome Institute of Singapore, Singapore
Xiao-Fan Wang, Duke University, Durham, NC, USA
Tian Xu, HHMI, Yale University, New Haven, CT, USA
Peter K. Vogt, The Scripps Research Institute, La Jolla, CA, USA
Geoffrey M. Wahl, The Salk Institute, La Jolla, CA, USA
William N. Hait, Cancer Institute of New Jersey, New Brunswick, NJ, USA
Program
Tuesday, Oct. 24th
8:00am – 8:30am Check-in
8:30am – 9:00am OPENING REMARKS
9:00am – 11:50am PLENARY SESSION 1: FUTURE CANCER RESEARCH DIRECTIONS
9:00am – 9:35am Stephen H. Friend (Merck Research Laboratories, Upper Gwynedd, PA, USA)
"Future models for oncology drug development"
9:35am – 9:50am Discussion
9:50am – 10:10am Tea Break
10:10am – 10:45am Charles L. Sawyers (HHMI, Memorial Sloan-Kettering Cancer Center, New York, NY, USA)
"New frontier and future medicine"
10:45am – 11:00am Discussion
11:00am – 11:35am Stephen B. Baylin (Johns Hopkins University, Baltimore, MD, USA)
"DNA methylation and gene silencing in cancer"
11:35am – 11:50am Discussion
11:50am – 1:00pm Lunch
1:00pm – 3:00pm additional speakers from School of Medicine, Jiaotong University, Shanghai
3:00pm – 5:50pm PLENARY SESSION 2: TARGET IDENTIFICATION
3:00pm – 3:35pm René Bernards (The Netherlands Cancer Institute, Amsterdam, The Netherlands)
"New tools for cancer genetics"
3:35pm – 3:50pm Discussion
3:50pm – 4:25pm James M. Roberts (HHMI, Fred Hutchinson Cancer Research Center, Seattle, WA, USA)
"Targeting cell cycle"
4:25pm – 4:40pm Discussion
4:40pm – 5:00pm Tea Break
5:00pm – 5:35pm Tian Xu (HHMI, Yale University, New Haven, CT, USA)
"Utilizing model organisms to understand tumorigenesis and metastasis"
5:35pm – 5:50pm Discussion
6:00pm – 8:30pm Breakout Small Group Dinner and Discussion
Wednesday, Oct. 25th
9:00am – 11:50am PLENARY SESSION 3: CLINICAL OPPORTUNITIES
9:00am – 9:35am Edison T. Liu (Genome Institute of Singapore, Singapore)
"Towards predictive cancer therapy"
9:35am – 9:50am Discussion
9:50am – 10:25am William G. Kaelin, Jr. (HHMI, Dana-Farber Cancer Institute, Boston, MA, USA)
"Context-specific cancer therapy"
10:25am – 10:40am Discussion
10:40am – 11:00am Tea Break
11:00am – 11:35am William N. Hait (AACR President-Elect, Cancer Institute of New Jersey, New Brunswick, NJ, USA)
“Oncology Care in the second decade of the 21st Century”
11:35am – 11:50am Discussion
11:50pm – 1:00pm Lunch
1:00pm – 3:00pm Breakout Small Group Activities
3:00pm – 6:40pm PLENARY SESSION 4: SIGNALING PATHWAYS
3:00pm – 3:35pm Qimin Zhan (Chinese Academy of Medical Sciences, Beijing, China)
"Cellular response to DNA damage"
3:35pm – 3:50pm Discussion
3:50pm – 4:25pm Xiao-Fan Wang (Duke University, Durham, NC, USA)
"Extracellular proteins and tumor metastasis"
4:25pm – 4:40pm Discussion
4:40pm – 5:00pm Tea Break
5:00pm – 5:35pm Geoffrey M. Wahl (AACR President, The Salk Institute, La Jolla, USA)
“Understanding p53 Regulation to Develop More Effective p53 Activators”
5:35pm – 5:50pm Discussion
6:00pm – 8:30pm Breakout Small Group Dinner and Discussion
Thursday, Oct. 26th
9:00am – 11:50am PLENARY SESSION 5: NEW CONCEPTS IN ONCOLOGY
9:00am – 9:35am Peter K. Vogt (The Scripps Research Institute, La Jolla, CA, USA)
"From viral oncoprotein to drug target"
9:35am – 9:50am Discussion
9:50am – 10:25am Zhu Chen (Chinese Academy of Sciences, Beijing, China)
"Systems biology of hematopoiesis and leukemia"
10:25am – 10:40am Discussion
10:40am – 11:00am Tea Break
11:00am – 11:35am Jianren Gu (Shanghai Cancer Institute, Shanghai, China)
"Genes in cancer development and progression"
11:35am – 11:50am Discussion
11:50pm – 1:00pm Lunch
1:00pm – 3:00pm Breakout Small Group Activities
3:00pm – 6:40pm PLENARY SESSION 6: NEW FRONTIER IN DEVELOPING THERAPIES
3:00pm – 3:35pm Alan D. D'Andrea (Dana-Farber Cancer Institute, Boston, MA, USA)
"The Fanconi anaemia/BRCA pathway "
3:35pm – 3:50pm Discussion
3:50pm – 4:25pm James R. Downing (St. Jude Children's Research Center, Memphis, TN, USA)
"Genomic assessment of pediatric acute leukemia"
4:25pm – 4:40pm Discussion
4:40pm – 5:00pm Tea Break
5:00pm – 5:35pm Paul Workman (Cancer Research UK, Sutton, England)
"Drugging the cancer genome: New drugs on the horizon"
5:35pm – 5:50pm Discussion
5:50pm - 6:10pm Closing Remarks
6:20pm – 8:30pm Banquet
