安捷伦“真核转录调控”技术交流会

地点：北京大学-生命科学学院--新生命科学大楼报告厅 （一层）

时间：2006年6月20日

日程安排：

1、10:00 - 10:05

Introduction: Shuolin SONG, Ph.D. Asia Pacific Marketing Manager, Agilent Technologies

2、10:05 - 11:00

Eukaryotic Transcriptional Regulatory Networks: Dr. Tony Lee of MIT

Bio of Dr. Tony Lee:

Tony Lee has a Ph.D degree from the MIT and a B.A. from Harvard College. He has been at the Whitehead Institute since 1994 and currently holds the title of Research Scientist. He has co-authored serveral papers in the fields of transcriptional regulation and led serveral of the pioneering efforts on genome-wide expression and chromatin immunoprecipitation technology in the laboratory of Richard Young.

Abstract:

Genome sequence encode the gene expression programs that contribute to development and differentiation, but how the cell controls global gene expression programs is far from understood. With the availability of complete genome sequences and a method for locating proteins on a genome-wide scale, we are noew in the process of building regulatory networks including transcription factors, chromatin modifying factors and other celluar components in serveral model systems.

Human ES cells, which can be maintained in an undifferentiated state but selectively induced to differentiate into specialized cell types, are thought to hold great promise for regenerative medicine. polycomb group proteins are a subset of proteins previously identified as essential for early development in metazoans but their contributions to the gene expression programs that control development and ES cell identity are still unclear. We have now mapped the polycomb Repressive Complex 2 (PRC2) subunit Suz12 across the entire non-repeat protion of the genome in human ES cells. We found that Suz12 is distributed across large portions of over two hundred genes encoding key developmental regulators. PRC2 target genes are preferentially activated during ES cells differentiation and the ES cell regulators Oct4, Sox2 and Nanog co-occupy a significant subset of these genes. These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation.

联系人：方晶

联系电话：021-23017667

主办单位