PNAS新“掌门人”：Randy Schekman
来自美国10月17日的最新消息，著名的《美国国家科学院院刊》（Proceedings of the National Academy of Sciences，PNAS)期刊经过60多名候选人的筛选，终于产生了新一任的总编（editor-in-chief）人选：Randy Schekman。Randy Schekman来自美国顶级学府加州大学伯克利分校（生物科学最新美国大学排名中与哈佛大学，麻省理工并列排名第二）。
Schekman毕业于斯坦福大学（生物化学博士学位），并于加州大学圣地亚哥分校进行了博士后研究，目前受任与加州大学伯克利分校细胞与发育生物学系，以及霍德华休斯医学院。其主要从事的研究领域为酿酒酵母细胞内蛋白运输的调控与机制，尤其是其中的分泌过程和在细胞器官中组装。其它研究领域还包括酶学，遗传学和电子显微等。
PNAS是世界上被引用次数最多的综合学科丛书之一。自1914年创刊至今，PNAS主要致力于前沿研究报告(cutting-edge research reports)、学术评论(commentaries)、学科回顾(reviews)及前瞻(perspectives)、学术论文(colloquium papers)以及美国国家科学学会学术动态的报道和出版(actions of the Academy)。PNAS收录的文献涉及了生物学、自然科学和社会科学等学科，每两周出版一期印刷版。2004年，PNAS的SCI影响因子为10.452。网络版PNAS（PNAS Online）始创于1997年1月，提供1990年以来在PNAS上刊出的所有文献的摘要、全文、图表、公式及参考文献。
Publications:
Simeon A. Boyadiev, J. Christopher Fromme, Jin Ben, Samuel S. Chong, Christopher Nauta, David J. Hur, George Zhang, Susan Hamamoto, Randy Schekman, Mariella Ravazzola, Lelio Orci & Wafaa Eyaid
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal ER-to-Golgi trafficking. Nature Genetics (2006), in press.
Wang, C. W., Hamamoto, S., Orci, L., and Schekman, R.
Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J. Cell Biol. (2006), in press.
Sanchatjate, S., and Schekman, R.
Chs5/6 Complex: A Multi-Protein Complex That Interacts with and Conveys Chitin Synthase III from the Trans-Golgi Network to the Cell Surface. Mol. Biol. Cell. 2006 Jul 19. Abstract.
Lee, M.C.S., Orci, L., Hamamoto, S., Futai, E., Ravazzola, M., and Schekman, R.
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell 122, 605-617 (2005). Abstract.
Miller, E. A., Liu, Y., Barlowe, C., and Schekman, R.
ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p. Mol. Biol. Cell. 16, 3719-3726 (2005). Abstract.
Fromme, J.C., and Schekman, R.
COPII-coated vesicles: flexible enough for large cargo? Curr. Opin. Cell Biol. 17, 345-352 (2005). Abstract.
Schekman, R.
Peroxisomes: another branch of the secretory pathway? Cell 122, 1-2 (2005). Abstract.
Futai, E., and Schekman, R.
Purification and functional properties of Sec12 GEF. Meth Enzymol. 404, 74-82 (2005). Abstract.
Wickner, William and Schekman, Randy.
Protein translocation across biological membranes. Science 310, 1452-1456 (2005). Abstract.
Schekman, R.
Membrane traffic in landmark papers in yeast biology, a chapter in Landmark Papers. Cold Spring Harbor Press (Eds. P. Linder, D. Shore and M. Hall) pgs. 243-252 (2005).
Kim, Jinoh, Hamamoto, Susan, Ravazzola, Mariella, Orci, Lelio, and Schekman, Randy.
Uncoupled packaging of amyloid precursor protein and presenilin 1 into COPII vesicles. J. Biol. Chem. 280, 7758-7768 (2004). Abstract.
Sun, Yidi, Kaksonen, Marko, Madden, David T., Schekman, Randy, and Drubin, David G.
Interaction of Sla2p's ANTH domain with PtdIns(4,5)P2 is important for actin-dependent endocytic internalization. Mol. Biol. Cell 16, 717-730 (2004). Abstract.
Malkus, Per, Graham, L. A., Stevens, T. H., and Schekman, Randy.
Role of Vma21p in assembly and transport of the yeast vacuolar ATPase. Mol. Biol. Cell 15, 5075-5091 (2004). Abstract.
Futai, Eugene, Hamamoto, Susan, Orci, Lelio and Schekman, Randy.
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. EMBO J. 23, 4286-4296 (2004). Abstract.
Schekman, Randy.
A channel for protein waste. Nature 429, 817-818 (2004). Article.
Schekman, Randy.
Merging cultures in the study of membrane traffic. Nature Cell Biol. 6, 483-486 (2004). Abstract.
Lee, Marcus C. S., Miller, E. A., Goldberg, J., Orci, L., and Schekman, Randy.
Bi-directional protein transport between the ER and Golgi. Annu. Rev. Cell Dev. Biol. 20, 87-123 (2004). Abstract.
Kim, Jinoh, and Schekman, Randy.
The ins and outs of presenilin 1 membrane topology. PNAS 101, 905-906 (2004). Article.
Lee, Marcus C. S., and Schekman, R.
BAR domains go on a bender. Science 303, 479-480 (2004). Article.
Schekman, Randy, and Novick, Peter.
23 genes, 23 years later. Cell S116, S13-S15 (2004). Article.
Antonny, B., Gounon, P., Schekman, R., and Orci, L.
Self-assembly of minimal COPII cages. EMBO Reports 4, 419-424 (2003). Abstract.
Valdivia, R., and Schekman, R.
The yeast Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane. Proc. Natl. Acad. Sci. USA 100,10287-10292 (2003). Abstract.
Miller, E., Beilharz, T. H., Malkus, P. N., Lee, M.C.S., Hamamoto, S., Orci, L., and Schekman, R.
Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114, 1-20 (2003). Abstract.
Harsay, E., and Schekman, R.
A subset of yeast vacuolar protein sorting mutants are blocked in one branch of the exocytic pathway. J. Cell Biol. 156, 271-286 (2002). Abstract.
Valdivia, R. H., Baggott, D., Chuang, J. S., and Schekman, R. W.
The yeast clathrin adaptor protein complex-1 is required for the efficient retention of a subset of late-Golgi membrane proteins. Dev. Cell 2, 283-294 (2002). Abstract.
Marcus C.S. Lee, Susan Hamamoto, and Randy Schekman
Ceramide biosynthesis is required for the formation of oligomeric H+-ATPase, Pma1p, in the yeast endoplasmic reticulum .J. Biol. Chem., 277, 22395-22401 (2002). Abstract.
Shimoni, Y., and Schekman, R.
Vesicle budding from the ER. Meth. Enzymol. 351, 258-278 (2002).
Supek, F., Madden, D. T., Hamamoto, S., Orci, L., and Schekman, R.
Sec16p potentiates the action of COPII proteins to bud transport vesicles. J. Cell Biol. 158, 1029-1038 (2002). Abstract.
Miller, E., Antonny, B., Hamamoto, S., and Schekman, R.
Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J. 21, 6105-6113 (2002). Abstract.
Schekman, R.
SEC mutants and the secretory apparatus. Nature Medicine 8, 1055-1058 (2002).
Deloche, O., and Schekman, R. W.
Vps10p cycles between the TGN and the late endosome via the plasma membrane in clathrin mutants. Mol. Biol. Cell 13, 4296-4307 (2002). Abstract.
Malkus, P., Jiang, F., and Schekman, R.
Concentrative sorting of secretory cargo proteins into COPII-coated vesicles. J. Cell Biol. 159, 915-921 (2002). Abstract.
Deloche O, Yeung BG, Payne GS, Schekman R.
Vps10p Transport from the trans-Golgi Network to the Endosome Is Mediated by Clathrin-coated Vesicles. Mol Biol Cell. 12, 475-485 (2001). Abstract.
Spang, A., Herrmann, J. M., Hamamoto, S., and Schekman, R.
The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol. Biol. Cell 12, 1035-1045 (2001). Abstract.
Antonny, B., Madden, D., Hamamoto, S., Orci, L., and Schekman, R.
Dynamics of the COPII coat with GTP and stable analogues. Nature Cell Biol. 3, 531-537 (2001). Abstract.
Antonny, B., and Schekman, R.
ER export: Public transportation by the COPII coach. Curr. Opin. Cell Biol. 13, 438-443 (2001). Abstract.
Lederkremer, G. Z., Cheng, Y., Petre, B. V., Vogan, E., Springer, S., Schekman, R., Walz, T., and Kirchhausen, T.
Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. PNAS 98, 10704-10709 (2001). Abstract.
Matsuoka, K., Schekman, R., Orci, L., and Heuser, J.
Surface structure of the COPII-coated vesicle. PNAS 98, 13705-13709 (2001). Abstract.
- 众说风云 (已有0条评论)
