杨向中博士简介

Faculty Member Profile Xiangzhong (Jerry) Yang Professor Joined UConn Animal Science Department in 1996

Background:

Dr. Xiangzhong Yang, known as Jerry to his colleagues, is a Professor of Animal Science and Head of the Transgenic Animal Facility of the UCONN Biotechnology Center. He received his BS degree from China Agricultural University in 1982, majoring in Animal Science. He received his MS and Ph.D degrees in the Department of Animal Science at Cornell University in 1987 and 1990, respectively. Following a short postdoctoral training at Cornell in the areas of embryology and animal biotechnology from 1990-91, Dr. Yang was offered a position as a principal investigator and program director at Cornell's Department of Animal Science with the responsibility to develop a vibrant extramurally funded animal biotechnology program. In June 1996, Dr. Yang joined the faculty of the University of Connecticut to head the Biotechnology Center's Transgenic Animal Facility.

Courses Taught:

ANSC 397

Animal Science Seminar

Research Interests:

Visit the Yang Lab Homepage

Dr. Yang's research has involved both basic reproductive biological research and practical animal biotechnology such as transgenesis and animal cloning. Dr. Yang is particularly well known in his field for his contributions to the development of embryo genetic manipulation techniques. In June 1998, his team introduced Amy, the calf, the first cloned animal from an adult farm animal in the United States. Further information regarding Dr. Yang's research can be found in a September 3, 2000, New York Times article entitled "This is Not Your Father's Agricultural School"

Dr. Yang's specific research interests follow:

- to study molecular and cellular regulation of mammalian oocyte maturation;

- to investigate the mechanism of ooctye activation and fertilization;

- to examine problems and scientific basis of animal cloning (nuclear transfer)

- to develop transgenic farm animals as potential bioreactors to produce human recombinant proteins as xenograft donors for cell, tissue and organ based therapy in humans.

Recent Publications:

Kubota C, Tian XC, and Yang X. Differential fertility in second and third generation clones of a prize breeding bull. Nature Biotechnology, June issue 2004 (available online 5/24/04, with worldwide press release by Nature press)

Nedambale, T.L., Dinnyes, A., Groen, W. Dobrinsky, J.R., Tian, X.C. and Yang, X. Comparison on in vitro fertilized bovine embryos cultured in KSOM or SOF and Cryopreserved by slow freezing or vitrification. Theriogenology (advanced publication online, Feb, 2004), 2004.

Chang CC, Nagy P, Abdelmassih R, Yang X, Tian XC. Nuclear and microtubule dynamics of G2/M somatic nuclei during haploidization in germinal vesicle-stage mouse oocytes. Biol Reprod 70:752-758, 2004.

Lee, J.W., Tian, X-C. and Yang, X., Optimization of parthenogenetic activation protocol in porcine. Mol Reprod Dev 68: 51-57, 2004.

Lee, J.W., Tian, X-C. and Yang, X., Factors affecting fertilization of porcine oocytes following intracytoplasmic injection of sperm. Mol Reprod Dev 68: 96-102, 2004.

Liu, J.L., Kusakabe, H., Chang, C.C., Suzuki, H., Schmidt, M., Julian, M., Pfeffer, R., Bormann, C., Tian, X-C., Yanagimachi, X. and Yang, X. Freeze-dried sperm fertilization led to term development in rabbits. Biol Reprod 70: 1776-1781, 2004 (with worldwide press release by Biol Reprod).

Liu, J.L., Sung, L.Y. Du, F., Julian, M., Jiang, S. Barber, M., Xu, J, Tian, X-C. and Yang, X. Differential development of rabbit embtyos derived from parthenogenesis and nuclear transfer. Mol Reprod Dev 68:58-64, 2004.

Yang, X. An embryonic nation. Nature 428: 210-212, 2004 (with worldwide release by Nature).

Nedambale TL, Dinnyés A, Yang X, Tian XC. Bovine blastocyst development in vitro: Timing, sex and viability following vitrification. Biol Reprod (accepted), 2004.

Xu, J. and Yang, X. Science, technology and potential applications of therapeutic cloning. Engineering in Medicine and Biology Magazine (in press), 2004.

Yang, X. Reproductive versus therapeutic cloning: Science, application and policies. Engineering in Medicine and Biology Magazine (in press), 2004.

Tian XC, Kubota C, Enright B, Yang X. Cloning animals by somatic cell nuclear transfer – biological factors. Reprod Biol Endocrinol 1:98-104, 2003.

Jiang L, Carter DB, Xu J, Yang X, Prather RS, Tian XC. Telomere lengths in cloned transgenic pigs. Biol Reprod 70:1589-1593, 2004.

Enright BP, Kubota C, Yang X, Tian XC. Epigenetic characteristics of donor cells treated by Trichostatin A or 5-aza-2’-deoxycytidine and development of embryos cloned from treated donor cells. Biol Reprod 69:896-901, 2003.

Enright BP, Jeong BS, Yang X, Tian XC. Epigenetic characteristics of bovine donor cells for nuclear transfer: Levels of histone acetylation. Biol Reprod 69:1525-1530, 2003.

AF Savage, J Maull, XC Tian, M Taneja, L Katz, M Darre and X Yang. Behavioral Observations of Adolescent Holstein Heifers Cloned from Adult Somatic Cells. Theriogenology 60:1097-1110. 2003.

Lee J, Wu S-C, Tian X, Barber M, Hoagland T, Riesen J and Yang X. Production of Cloned Pigs by Whole Cell Intracytoplasmic Microinjection. Biol Reprod 69:995-1001, 2003 (BOR press release, featured by a Nature science online news feature article).

Lee, JW, Tian, XC, and Yang X. Failure of male pronuclear formation is the major cause for the lack of fertilization and embryo development in pig ICSI oocytes. Biol Reprod 68:1341-1347. 2003.

Suzuki H, Saito Y, Kagawa N, and Yang X. In vitro fertilization and polyspermy in the pig: Factors affecting fertilization rates and cytoskeletal reorganization of the oocyte. Scan Elec Micros 61:327-334, 2003

Xu J and Yang X. Will Cloned Animals Suffer Premature Aging - The Story at the End of Clones’ Chromosomes. Reprod Biol Endo 1: 105-110, 2003

Tian XC, Kubota C, Enright B, Yang X. Cloning animals by somatic cell nuclear transfer – biological factors. Reprod Biol Endo 1: 98-104, 2003.

Yang X (forum editor). Toward therapeutic cloning and regenerative biology forum: To clone or not to clone. Reprod Biol Endo 1: 97 (4 pages), 2003

Enright, B.P., Kubota, C., Yahng, X., Tian, X.C. Epigenetic Characteristics of Donor Cells treated by Trichostatin A or 5-Aza-2'- deoxycytidine and development of embryos cloned from treated donor cells. Biol Reprod (in press). 2003.

Enright, B.P., Jeong, B.S., Yang, X., Tian, X.C. Epigenetic Characteristics of in vitro Cultured Donor Cells for Nuclear Transfer: Levels of Histone Acetylation. Biol Reprod (accepted) 2003.

Lee, J.W., Wu, S.C., Tian, X.C., Barber, M., Hoagland, T., Riesen, J., Yang, X. Production of Cloned Pigs by Whole Cell Intracytoplasmic Microinjection. Biol Reprod (in press) 2003.

Lee, J.W., Tian, X.C., Yang, X. Failure of male pronucleus formation is the major cause for the lack of fertilization and embryo development in pig ICSI oocytes. Biol Reprod 68:1341-1347. 2003.

Lee, J.W., Tian, X.C., Yang, X. Optimization of Parthenogenetic Activation Protocol in Porcine. Mol Reprod Dev (in press). 2003.

Savage, A.F., Maull, J., Tian, X.C., Taneja, M., Katz, L., Darre, M., Yang, X. Reproductive Characteristics of Cloned Heifers Derived from Adult Somatic Cells. Theriogenology 60 (3) (in press) 2003.

Dinnyes, A., Tian, X.C., Yang, X. Cloning of Rabbits (Chapter 17). In: Principles of Cloning. Eds. JB Cibelli, RP Lanza, KHS Campbell and MD West. Academic Press, San Diego, CA. pp. 344-366, 2002.

Du, F., Sung, L-Y., Tian, X.C. and Yang, X. Differential Cytoplast Requirement for Embryonic and Somatic Cell Nuclear Transfer in Cattle. Mol Reprod Dev (accepted) 2002.

Enright, B., Taneja, M., Schreiber, D., Riesen, J., Tian, X.C., Fortune, J.E., Yang, X. Reproductive Characteristics of Cloned Heifers Derived from Adult Somatic Cells. Biol. Reprod. 66:291-296. 2002.

Govoni, K.E., Tian, X.C., Kazmer, G.W., Taneja, M., Enright, B., Rivard, A.L., Yang, X., Zinn, S.A. Age-related changes of the somatotropic axis in cloned Holstein calves. Biol Reprod 66:1293-1298 2002.

Liu, J.L., Sung, L.Y., Barber, M., Yang, X. Hypertonic Medium Treatment for Localization of Nuclear Material in Bovine Metaphase II Oocytes. Biol. Reprod. 66:1342-1349. 2002.

Liu, J.L., Sung, L.Y., Tian, X.C., Yang, X. Hypertonicity-Induced Projections Reflect Cell Polarity in Mouse MII Oocytes: Involvement of Microtubules, Microfilaments, and Chromosomes. Biol Reprod 67:1853-1863 2002.

Liu, L., Deng, M., Tian, X.C., Yang, X. Chapter 17. Principles of Practice of oocyte activation in mammals. In: Introduction to Mammalian Reproduction. Daulat R.P. Tulsiani, Kluwer Academic Publishers, MA, USA, pp 319-345.

Liu, J.L., Sung, L.Y., Barber, M., Yang, X. Hypertonic Medium Treatment for Localization of Nuclear Material in Bovine Metaphase II Oocytes. Biol. Reprod. 66:1342-1349. 2002.

Tian, X.C., Lonergan, P., Jeong, B.S., Evans, A.E.O., Yang, X. Association of MPF, MAPK and nuclear progression dynamics during activation of young and aged bovine oocytes. Mol Reprod Dev 62:132-138. 2002.

Xue, F., Tian, X.C, Kubota, C, Du, F., Taneja, M., Dinnyes, A., Dai, Y., Lewin, H., Pereira, L.V. and Yang, X. Aberrant patterns of X-Chromosome inactivation in bovine clones. Nature Genetics 31:216-220, 2002.

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