王海洋博士简介

生物谷

王海洋博士，研究员 Haiyang Wang, Ph.D., Assistant Investigator, National Institute of Biological Sciences, Beijing.
电话（Tel）：010-80726688
传真（Fax）：010-80726689
E-mail：wanghaiyang@nibs.ac.cn

教育经历Education
1986年浙江大学生物系学士
B.S. Biology, 1982-1986,
Zhejiang University, China
1998年美国密执根大学博士
Ph.D Biology, 1992-1998,
The University of Michigan, USA
工作经历Professional Experience
2004-present National Institute of Biological Sciences, Beijing, China（中国北京生命科学研究所工作）
2002-present Assistant Scientist, Boyce Thompson Institute for Plant Research, Cornell University（康奈尔大学Boyce Thompson植物研究所助理科学家）
1998-2002 Postdoctoral research with Dr. Xing Wang Deng at the Department of MCDB, Yale University（耶鲁大学分子与细胞发育生物学系邓兴旺实验室从事博士后研究）
1992-1998 Graduate work with Dr. John Schiefelbein at the Department of Biology, University of Michigan（密执根大学生物系John Schiefelbein实验室进行博士生研究）

1989-1992 Research assistant (supervisors Dr. Fu-hsiung Wang and Dr. Yu-shi Hu), Institute of Botany, The Chinese Academy of Sciences（中国科学院植物研究所研究助理）
1986-1989 Graduate student (advisor Dr. Zhenghai Hu), Department of Biology, Northwest University of China（西北大学生物系研究生）
研究概述：
该实验室的研究方向主要是运用拟南芥作为模式系统来探索植物光敏素A信号传导以及植物光形态建成的分子生物学、细胞学、和生物化学机制。
光是植物生长发育的主要环境影响因素之一，而且是作物产量的重要决定因子。植物几乎能够感受各种层次的光，包括光照方向、光照持续时间、光量度以及光的波长。而感受这些光主要是通过三种光受体，分别为隐花色素受体、向光色素受体和光敏色素受体。隐花色素和向光色素受体吸收的是蓝光和紫外光A区域的光线，而光敏色素主要吸收的是红光和远红光波长的光。在这些光受体中，对光敏色素受体的作用特点研究的最为清楚。在拟南芥中有五种不同的光敏色素，分别被命名为phyA到phyE。这些光敏色素受体在不同的光形态建成反应中所起的作用有时是不同的，有时有部分的冗余甚至相反的作用。PHYB到PHYE

的基因表达产物主要是在连续的红光和白光的光照条件下调控各种光反应。PhyA主要在各种远红外光调控的反应中起作用。
本研究室主要寻找和研究一些参与phyA信号传导的中介基因。目的是为了阐明光敏色素A接受信息并且把信息传递到靶基因的生化和细胞学机制，从而了解光是怎样调节基因表达进而导致了光形态建成。
Research Description：
Research in the Wang laboratory is primarily focused on understanding the molecular, cellular and biochemical mechanisms underlying phytochrome A signaling and plant photomorphogenesis using Arabidopsis as a model system.
Light is one of the major environmental signals that influences plant growth and development, and as such is a critical determinant of crop productivity. Plants can detect almost all aspects of light, including direction, duration, quantity, and wavelength, using three major classes of photoreceptors: The cryptochromes and phototropins monitor the blue/ultraviolet-A (B/UV-A) region of the spectrum, whereas the phytochromes monitor primarily the red (R) and far-red (FR) wavelengths. Among these photoreceptors, phytochromes are the best characterized. There are five distinct phytochromes in Arabidopsis, designated phyA to phyE. These photoreceptors have unique, sometimes partially redundant, or antagonistic roles in different photomorphogenic responses. The gene products of PHYB to PHYE predominantly regulate light responses under continuous red and white light. phyA is primarily responsible for various far-red light regulated responses.
My research group is interested in identifying genes (signaling intermediates) involved in the phyA signaling process, elucidating the biochemical and cellular mechanisms by which phyA relays perceived information to target genes, and understanding how light regulated gene expression leads to photomorphogenic development.

发表文章 Publications:
1. Saijo*, Y., Sullivan*, J. A., Wang*+, H. , Yang+, J., Shen, Y., Rubio, V. , Ma, L., Hoecker, U., and Deng, X.W. 2003. The COP1-SPA1 interaction defines a critical step in phytochorme A-mediated regulation of HY5 activity. Genes & Development, 17: 2642-2647. *: These authors contributed equally to this work. +: Wang, H. and Yang, J. are from Boyce Thompson Institute).
2. Wang, H. and Deng, X. W. 2003. Phytochrome A-regulated signaling network and

photomorphogenesis. Trends in Plant Sci. 8, 172-178.
3. Yi, C., Wang, H., Wei, N., and Deng X.W. 2002. An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1. BMC Cell Biology 3:30.
4. Wang, H., Ma, L.-G., Li, J.-M., Zhao, H.-Y., and Deng, X.W. 2002. Analysis of far-red light regulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis. The Plant Journal, 32:723-733.
5. Wang, H., Lee, M.M., and Schiefelbein, J. 2002. Regulation of the cell expansion gene RHD3 during Arabidopsis development. Plant Physiology, 129:638-649.
6. Wang, H. and Deng, X.W. 2002a. Arabidopsis FHY3 defines a key phytochrome A signaling component directly interacting with its homologous partner FAR1. EMBO J., 21:1339-1349.
7. Wang, H. and Deng, X.W. 2002b. Phytochrome Signaling Mechanism. In The Arabidopsis Book. eds. Elliot Meyerowitz and Chris Somerville. American Society of Plant Biologists. http://www.aspb.org/publications/arabidopsis/.
8. Wang, H., Ma, L.-G., Li, J.-M., Zhao, H.-Y., and Deng, X.W. 2001. Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science, 294: 154-158.
9. Wang, H., Kang, D., Deng, X.-W., and Wei, N. 1999. Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. Current Biology, 9:711-714.
10. Wang, H., Ford, S., Hoeltzel, M., and Schiefelbein, J. 1997. The Root Hair Defective3 gene encodes an evolutionarily conserved protein with GTP-binding motifs and is required for regulated cell enlargement in Arabidopsis. Genes & Dev. 11:799-811.
11. Schiefelbein, J., Masucci, J., and Wang, H. 1997. Building a Root: The control of patterning and morphogenesis in root development. Plant Cell, 9:1089-1098.
12. Kinkema, M., Wang, H., and Schiefelbein, J. 1994. Molecular analysis of the myosin gene family in Arabidopsis thaliana. Plant Molecular Biology, 26:1139-1153.
13. Wang, H., Hu, Y., and Wang, F. 1995. Anatomy of gymnosperms endemic to China III. Pseudotaxus chienii Cheng. Cathaya 7:147-163.
14. Hu, Y., Wang, H., and Wang, F. 1992. Leaf anatomy of Austrataxus in relation to its systematic position. Cathaya, 4:69-77.
15. Wang, H. and Hu, Y. 1992. On the structure of the female reproductive organs of Taxaceae and its systematic position. Botanical Research, No. 7:42-47.
16. Wang, H. and Hu, Y. 1992. Structure and development of sieve cells in gymnosperms. Chinese Bulletin of Botany, 9:23-26.
17. Wang, H. and Hu, Y. 1992. Albuminous cells. Chinese Bulletin of Botany, 9:17-20.
18. Wang, H., Hu, Z., and Tien, L. 1990. The changes of the intracellular materials of wheat during the differentiation of the flower and inflorescence. J. Northwest Univ. N. 3.1990, Vol. 20:63-68.
19. Wang, H., Tien, L., and Hu, Z. 1989. Study on the histogenesis of the flower and inflorescence of Triticum aestivum L. Act. Bot. Bor.-Occ. Sinica, 9:136-143.