郭岩

生物谷

郭岩博士，研究员 Yan Guo, Ph.D., Assistant Investigator, National Institute of Biological Sciences, Beijing.
电话（Tel）：010-80726688-8523
传真（Fax）：80726671
E-mail：guoyan@nibs.ac.cn

教育经历Education
1988年北京农业大学农学系植物育种学专业学士
B.S. Plant Breeding, Department of Agronomy, 1988
Beijing Agricultural University, China
1999年德国科隆大学遗传学系、德国科隆马普植物育种所植物分子遗传学博士
Ph.D. Plant Genetics and Molecular Biology, Max-Planck-Institute for Plant Breeding, Cologne, Germany, and Department of Genetics, 1999,
University of Cologne, Germany
工作经历Professional Experience
2004-present National Institute of Biological Sciences, Beijing, China（中国北京生命科学研究所工作）
1999-2003 Postdoctoral Research Associate with Dr. Jian-Kang Zhu, Department of Plant Sciences, University of Arizona, Tucson, Arizona，USA（美国亚利桑那州图森市亚利桑那大学植物科学系朱健康博士实验室做博士后研究）
1995-1999 Ph.D. Student with Dr. Richard Thompson, Max-Planck-Institute for Plant Breeding, Cologne, Germany（德国科隆马普育种所Richard D.Thompson 博士实验室读博士）
1988-1999 Research Assistant and Associate with Professor Shouyi Chen, Institute of Genetics, Chinese Academy of Sciences, Beijing, China（中国北京中国科学院遗传所陈受宜教授实验室做研究助理）
研究概述：Research Description
我们实验室的研究兴趣主要是植物如何感受并响应环境胁迫，诸如土壤高浓度盐、碱，及干旱，特别是植物在胁迫条件下体内Ca2+信号和pH内平衡的调节。
主要研究内容是利用拟南芥突变体研究植物感受环境胁迫信号过程中所发生的遗传和分子特性的变化。目的是为了阐明植物响应环境胁迫的信号路径，并鉴定一些具有潜在功能的能够提高作物适应环境胁迫的关键作用元件。

I am interested in studying how plants sense and respond to environmental stresses such as high soil salinity, alkalinity and drought. Particularly, I am interested in understanding regulation of Ca2+ signaling and pH homeostasis under these stresses in plants.
My research will involve genetic and molecular characterization of Arabidopsis mutants that are altered in response to environmental stimuli. The goals are to elucidate the plant signaling pathways in response to environmental stresses and to identify key components that can potentially be engineered for improvement of crop plants to encounter environmental stresses.

发表文章Publications:
1. Guo, Y., Qiu, Q.-S., Schumaker, K.S., and Zhu, J.-K. 2004. Transgenic evaluation of activated mutant alleles of SOS2 reveals a critical requirement of its kinase activity and C-terminal regulatory domain for salt tolerance in Arabidopsis. Plant Cell 16: 435-449.
2. Gong D., Guo Y., Schumaker K. S., and Zhu J-K. 2004. The SOS3 Family of Calcium Sensors and SOS2 Family of Protein Kinases in Arabidopsis. Plant Physiol. 134: 919-926.
3. Qiu, Q.-S., Guo, Y., Quintero F.j., Pardo J.M., Schumaker, K.S. and Zhu, J.-K. 2004. Regulation of vacuolar membrane Na+/H+ exchange in Arabidopsis thaliana by the SOS pathway. J Biol Chem. 279(1): 207-215.
4. Ohta, M., Guo, Y., Halfter, U. and Zhu J.K. 2003. A novel domain in the protein kinase SOS2 mediates interaction with the protein phosphatase 2C ABI2. Proc. Natl. Acad. Sci. USA. 100:11771-11776.
5. Shi, H., Kim, Y.-S., Guo Y., and Zhu, J.-K. 2003. The Arabidopsis SOS5 Locus Encodes a Putative Cell Surface Adhesion Protein and Is Required for Normal Cell Expansion. Plant Cell 15: 19-32.
6. Guo, Y., Xiong, L., Ishitani, M. and Zhu, J.-K. 2002. An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures. Proc. Natl. Acad. Sci. USA. 99:7786-7791.
7. Guo, Y., Xiong, L., Song, C.-P., Gong, D., Halfter, U. and Zhu, J.-K. 2002. A calcium sensor and its interacting protein kinase are global regulators of abscisic acid signaling in Arabidopsis. Dev. Cell. 3:233-244.
8. Qiu, Q.-S., Guo, Y., Dietrich, M.A., Schumaker, K.S. and Zhu, J.-K. 2002. Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3. Proc. Natl. Acad. Sci. USA. 99:8436-8441.
9. Gong, D., Guo, Y., Jagendorf, A.T. and Zhu, J.-K. 2002. Biochemical characterization of the Arabidopsis protein kinase SOS2 that functions in salt tolerance. Plant Physiol. 130:256-264.
10. Santandrea, G., Guo, Y., O'Connell, T. and Thompson, R.D. 2002. Post-phloem protein trafficking in the maize caryopsis: ZmTRXh1, a thioredoxin specifically expressed in the pedicel parenchyma of Zea mays L., is found predominantly in the placentochalaza. Plant Mol. Biol. 50:743-756.
11. Lee, H., Guo, Y., Ohta, M., Xiong, L., Stevenson, B. and Zhu, J.-K. 2002. LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase. EMBO J. 21:2692-2702.
12. Gong, D., Gong, Z., Guo, Y., Chen, X. and Zhu, J.-K. 2002. Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase. J. Biol. Chem. 277:28340-28350.
13. Gong, D., Gong, Z., Guo Y. and Zhu. J.-K. 2002. Expression, activation, and biochemical properties of a novel Arabidopsis protein kinase. Plant Physiol. 129:225-234.
14. Gómez, E., Royo, J., Guo, Y., Thompson, R. and Hueros, G. 2002. Establishment of cereal endosperm expression domains: Identification and properties of a maize transfer cell–specific transcription factor, ZmMRP-1. Plant Cell 14:599-610.
15. Guo, Y., Halfter, U., Ishitani, M. and Zhu, J.-K. 2001. Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance. Plant

Cell 13:1383-400.
16. Xiong, L., Gong, Z., Rock, C.D., Subramanian, S., Guo, Y., Xu, W, Galbraith, D. and Zhu, J.-K. 2001. Modulation of abscisic acid signal transduction and biosynthesis by an Sm-like protein in Arabidopsis. Dev Cell. 1:771-781.
17. Guo, Y., Zhang, L., Xiao, G., Cao, S., Gu, D., Tian, W. and Chen, S. 1997. Expression of the BADH gene and salinity tolerance in rice transgenic plants. Sci. in China 40:296-501.
18. Guo, Y., Chen, S., Zhang, G. and Chen, S. 1997. Salt-tolerance in rice mutant lines controlled by a major effector gene was obtained by a cell engineering technique. Acta Genet. Sin. 24:122-126.
19. Zhang,G.-Y., Guo, Y., Chen, S.-L. and Chen, S.-Y. 1995. RFLP tagging of a salt tolerance gene in rice. Plant Sci. 110:227-234.
20. Guo, Y., Chen, S.-L., Zhang, G.-Y. and Chen, S. 1993. Study on selection of HYP-resistant variants of rice and their characteristics. Acta Biol. Exp. Sin. 126: 5-10.