美疫苗公司Novavax与马里兰大学开发MERS疫苗

关键词:疫苗研发,Novavax,马里兰大学,MERS

2014年5月5日讯 /生物谷BIOON/ --不久前,美国疾控中心(The Centers for Disease Control and Prevention,CDC)宣布一名去过沙特阿拉伯的美国人感染了中东呼吸系统综合征冠状病毒(MERS),这也为这种病毒在美国的传播敲响了警钟。现在,美国的疫苗研发公司Novavax和马里兰大学的研究团队开发针对MERS的疫苗在动物实验上表现出了良好的效果。

据研究人员发表在Vaccine上的文章介绍,研究人员利用率一种新方法来快速制备针对未知病毒的疫苗。这种方法主要是利用了Novavax公司基于表面锚定蛋白的纳米颗粒疫苗技术。此前,Novavax公司就曾利用这种技术成功制备出SARS疫苗。

据了解,MERS已经引起沙特阿拉伯和美国有关部门的高度重视,沙特阿拉伯健康部门已经联合5个国际医药公司开发相关疫苗,并争取赶在MERS流行季节到来前上市。(生物谷Bioon.com)

详细英文报道:

With the arrival of Middle East respiratory syndrome coronavirus in the U.S. and a rising death toll in Saudi Arabia, a vaccine designed by Novavax ($NVAX) and the University of Maryland has shown promise in blocking the infection in animals.

In a study published in Vaccine, researchers describe a novel method to rapidly develop vaccines against previously unknown viruses, such as MERS-CoV, which emerge suddenly and cause severe illness in humans. The experimental MERS jab was developed using Novavax's nanoparticle vaccine technology based on a surface spike protein, or 'S' protein, on the MERS virus that is responsible for binding the virus to target cells.

In mice, the vaccine candidate induced neutralizing antibodies that effectively blocked the virus from infecting cells.

The University of Maryland and Novavax team also reported in the study that a vaccine candidate against severe acute respiratory syndrome coronavirus (SARS-CoV) using a similar platform also inhibited virus infection.

Experts have questioned the logic of spending millions on a potential vaccines and immunization efforts and instead point to the possibility of targeting the likely source of the viral outbreak--camels.

At the same time, Saudi Arabia's Health Ministry said in April that it was working with 5 international pharma companies to develop a vaccine, which could be available as soon as this fall.

The Centers for Disease Control and Prevention on May 2 confirmed the first U.S. case of MERS in a healthcare provider in Indiana with a history of travel to Saudi Arabia.

 

(责任编辑:lishuheng)

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