Beyond Genome国际会议在美国San Diego市举行

由CHI（Cambridge Healthtech Institute）组织的Beyond Genome国际会议于6月15-19在美国的San Diego市举行。此会议包括4个方面：Bioinformatics and Genome Research，Proteomics，RNA interference，Systems Biology，其中，Bioinformatics and Genome Research已是第12届了，Proteomics为第7届，Systems Biology为第5届，RNA interference为新列的专题。全美各大生物、医药公司都有研究人员参加，出席的也有世界其它国家的相关研究人员和生物医药公司的人员。报告的内容相当丰富，主要包括：怎样整合现有的生物信息，建立相关的信息提取和分析平台，怎样应用生物技术（包括生物信息学技术）进行药物的靶点发现和药物的设计，RNA interference作为未来生物制药的一个热点引起了大家的广泛兴趣。本中心的石铁流老师参加了此会，现将会议的有关报告的资料放到网上，有兴趣的人员可下载相关资料(PDF files)。

If you get these data, please click the link and download the PDF files

System Biology

• Bringing Genomes to Life: the use of in silico models

• Informatics Infrastructure for Systems Biology

• The Computational Versatility of the Simple Cascade

• Systems Biology Approach to Understand Cellular Functions

• The Silicon Cell and Network-Based Drug Design

• Toward Tools for Large-scale Simulations in Systems Biology

• Sifting Genomic Sequence through Comparative Analysis

• The use of well-defined in vitro models and gene expression profiling to identify novel therapuetic targets（powerpoint file）

• The Systems Biology Markup Language (SBML) Level 2

• Functional Implications of Alternative System Designs: Genetic Switches and Signal Transduction Modules

• Systems biology from an It perspective: Linking diverse biological data sources

• In Silico Approaches To Predicting Drug Metabolism, Toxicology and Beyond

• Discovery of Disease Markers Using a Systems Biology Approach

• Clonal Evolution of Cancer

• Applying the Entelos Metabolism PhysioLab to Pharmaceutical R&D

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RNA interference

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• RNAi Technology in Oncology Target Discovery and Validation

• RNAi in drug development

• Control of gene expression by microRNAs

• RNA-Interference as a Platform for the Development of Cancer Therapeutics

• Arrayed Adenoviral Knockdown Vectors for Target Discovery and Validation

• Efficient Strategies for Delivery of siRNAs to Mammalian Cells in vitro and in vivo

• Human Cervical Cancer: Caused by infection with Human Papilloma Virus (HPV)

• Mechanistic and therapeutic studies of siRNAs in mammalian cells

• Using RNAi/siRNA for functional characterization of CNS targets

• Tools for expediting target validation

• RNAi-Mediated Inhibition of HIV-1 Replication in Primary Macrophages

• Development for a Robust siRNA Screen & Using RNAi for Target Velidation

• Studying cancer using stable RNA interference tools

• APPLICATIONS OF siRNAs FOR INVESTIGATING HORMONE-REGULATED GROWTH OF BREAST CANCER CELLS

• Genome wide Knockdown Strategies: RNAi Application

• Developments in siRNA-Based Gene Silencing

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Bioinformatics and Genome Research

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• Novel Bioinformatics Techniques in Functional Genomics

• The Visualization of Statistical Significance and it’s Application to Microarrays

• Mapping Pathways from Genes to Brain Diseases with Applied Neuroinformatics

• Elucidating Biological Pathways by Integrating Gene Annotations and Gene Expression Data

• Practical Tools and Resources for Analysis, Biological Interpretation, and Integration of Microarray Data

• Identification of ATP-Binding Proteins Using Random Peptide Phage Display

• The Application of Bioinformatics and Molecular Approaches to the Study of Nuclear Receptors

• Bioinformatics of Protein Kinases

• From Networks of Molecular Associations to Drug Discovery Decision Support

• Informatics Methods for Correlating Molecular Structure with Genomic Data

• Rich subtext of gene expression deciphered through the lens of Gene Ontology

• Location Proteomics: Automated Interpretation of Fluorescence Microscope Images

• Solutions-based Interoperability in Life Science Informatics

• Systems Biology through Data Analysis and Simulation

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Proteomics

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• Quantitative Detection of Disease Markers in Serum Using Antibody Microarrays

• High-Performance Multidimensional Chromatography MALDI-QFTICR MS for “Bottom Up” Proteomics

• Clinical Biomarker Discovery With Rolling Circle Amplified Protein Chips

• NHLBI Proteomics Initiative to Develop and Apply Innovative Proteomics Technologies

• Proteomics San Diego, CA June 18th, 2003

• Amino Acid-Specific Mass Tagging for Proteomics

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