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Domain binding and function: The BRCT domain (BRCA1 C-terminus) is a conserved proteinÀprotein interaction region of approximately 95 amino acids found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. It was first identified in the breast cancer suppressor protein BRCA1 but is also found in DNA repair proteins such as DNA ligase III and XRCC1, which form strong heterodimers through their BRCT domains. The C-terminal BRCT domain of BRCA1 has been reported to bind to the central domain of p53, allowing BRCA1 to act as a coactivator of p53.
Structure Reference: Zhang, X. et al. (1998) EMBO J. 17(21), 6404À6411.
Examples of Domain Proteins:
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| The C-terminal BRCT domain of XRCC1. | |
