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Domain binding and function: Approximately 110 amino acids in length, the Bromo domain is found in many chromatin-associated proteins such as histone acetylases and the ATPase component of certain nucleosome-remodeling complexes. Bromo domains have been identified in over 100 proteins from yeast to man. The Bromo domains of PCAF and Gcn5p have been shown to interact specifically with peptides containing acetylated lysine residues. Recognition of acetyl-lysine is similar to that of acetyl-CoA by histone acetyltransferases, though the bromodomain is the only domain known to interact with acetylated lysineÀ containing peptides.
Structure Reference: Owen, D.J. et al. (2000) EMBO J. 19(22), 6141À6149.
Examples of Domain Proteins:
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| The Bromodomain of Gcn5p binding acetylated lysine (red). | |
