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Domain binding and function: The Shadow Chromodomain (CSD) is a 40À70 amino acid domain that occurs only in the context of proteins containing a chromodomain (CD). While the Shadow chromodomain resembles the chromodomain structurally, it appears to function in a distinct manner with respect to proteinÀprotein interactions. CSD lacks the hydrophobic sash believed to mediate CD interactions. Shadow chromodomains form stable dimers, and dimerization generates an interaction pit that may allow docking with partner proteins containing an extended hydrophobic pentapeptide motif.
Structure Reference: Cowieson, N.P. et al. (2000) Curr. Biol. 10(9), 517À525.
Examples of Domain Proteins:
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