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Domain binding and function: The FYVE (Fab-1, YOTB, Vac1 and EEA1) domain is a small, cysteine-rich Zn2+ binding domain of approximately 60 amino acids. To date, FYVE domains have been identified in over 200 different proteins from yeast to man. The FYVE domain has been shown to specifically bind PI(3)P. This observation has implicated FYVE domainÀcontaining proteins in a signaling role downstream of PI3 kinase. Furthermore, FYVE-containing proteins have been implicated in the regulation of the vacuolar/lysosomal membrane trafficking pathway and in regulation of signaling by TGFbeta-receptors.
Structure Reference: Misra, S. and Hurley, J.H. (1999) Cell 97(5), 657À666.
Examples of Domain Proteins:
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| The FYVE domain of Vps27p. | |
