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Domain binding and function: The glycine-tyrosine-phenylalanine, or GYF domain was first reported in the CD2 binding protein CDBP2 as a domain capable of binding to a proline-rich peptide sequence in the CD2 tail region. Despite functioning as a proline-rich peptide binding domain, the GYF fold is structurally unrelated to the SH3 or WW domains. The GYF domain of CDBP2 binds to a PPPPGHR repeat in the CD2 tail via a relatively smooth, concave surface that forms a continuous hydrophobic patch containing many of the GYF domainÀconserved residues.
Structure Reference: Freund, C. et al. (1999) Nat. Struct. Biol. 6, 656À660.
Examples of Domain Proteins:
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| The GYF domain of CD2BP2. | |
