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Domain binding and function: Pleckstrin-homology (PH) domains are found in a wide variety of signaling proteins that associate with membranes. Some PH domains bind with high affinity (low µM or nM Kd) to specific phosphoinositides such as phosphatidylinositol- 4,5-bisphosphate, PI-3, 4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/gamma subunits of heterotrimeric G-proteins.
Structure Reference: Ferguson, K.M. et al. (1995) Cell 83(6), 1037À1046.
Examples of Domain Proteins:
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| The PH domain from rat PLC delta1 bound to Ins(1,4,5)P3 (red). | |
