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Domain binding and function:The Phox homology (PX) domain is the most recently identified member of the family of phospholipid-binding domains. Consisting of ~120 amino acids, the PX domain is found in more than 100 proteins, including the p40phox and p47phox components of the NADPH oxidase complex, sorting nexins, phospholipases D1 and 2 and the kinases PI3K and CISK. Biochemical and cell biology studies have established that PX domains function predominantly as D3-phosphorylated phosphoinositide [PI(3)P] binding modules, targeting the PX domain-containing proteins to the membranes.
Structure Reference: Bravo, J. et al. (2001), Mol. Cell 8 (4), 829-839.
Examples of Domain Proteins:
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| The PX domain of human p40phox bound to PI(3)P (red). | |
