|
Domain binding and function: The approximately 70 amino acid SAM (Sterile Alpha Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating proteinøprotein interaction via the formation of homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined.
Structure Reference: Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44ø49.
Examples of Domain Proteins:
|
 |
| The SAM domain from the EphA4 receptor. | |
