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Domain binding and function: Both the CSD and BA START domain families share a common topology consisting of a seven stranded core beta sheet centered between a pair of alpha helices at the N-terminus and an alpha helix at the C-terminus. The C-terminal alpha helix is packed tightly against the sheet, consistent with a Helix-Grip type fold. A striking feature of the START domains is the long hydrophobic tunnel expanding throughout the length of the domain. By adopting a structure similar to an incomplete beta barrel, the interior face of the beta sheet forms the bottom and sides of this tunnel. The tunnel is in turn, roofed by the C-terminal helix.
Structure Reference: Tsujishita, Y. and Hurley, J.H. (2000) Nat. Struct. Bio 7(5), 408-444.
Examples of Domain Proteins:
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| The START domain of human MLN64. | |
