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Domain binding and function: WD40 repeats are found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, cytoskeleton assembly and cell cycle control. The only common functional theme of WD40 domains is to serve as a stable propeller-like platform to which proteins can bind either stably or reversibly. Unlike the non-WD40 propeller family of proteins, there are no cases of WD40 proteins with catalytic activity. The WD40 domains of beta-TRCP and Cdc4 have been implicated in recognizing phosphorylated serine and threonine containing peptides, demonstrating that in some cases WD40 repeat forming beta-propeller structures can serve in phospho-peptide recognition. Structure Reference: Wall, M.A. et al. (1995) Cell 83(6), 1047–1058.
Examples of Domain Proteins:
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Binding Examples:
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WD40 domain proteins |  |
Binding partners | |
Functions |  |
| G-Protein beta-Chain | G-protein alpha,gamma-chain | Signal transduction | ||||
| Prp4 Splicing Factor | Prp3 Splicing Factor | Splicing | ||||
| Tup1 Transcriptional Repressor | Alpha2 Transcriptional repressor | Transcription | ||||
| Cdc4 | phosphorylated Sic1 | Ubiquitination and Cell Cycle control |
