Aka Discoidin Domain Receptor 1, DDR1
Has homologous region to the Dicytostelium discoideum protein discoidin I in extracellular domain
Tyrosine kinase receptor, may be important in cytoskeletal organization and the ability to align with other cells during aggregation
Receptor tyrosine kinases help cells communicate with their microenvironment and regulate cell growth, differentiation and metabolism.
Activated by collagen types I-V, VIII
May have a role in tumor invasion and metastasis
Positive staining (normal): epithelial cells (breast, kidney, lung, GI, brain)
Positive staining (tumors): carcinomas (various)
CD168
Aka Receptor for Hyaluronic Acid-Mediated Motility (RHAMM)
Binding to hyaluron stimulates ciliary beating
Also has role in cell signaling, migration and adhesion
Positive staining (normal): bronchial epithelium, CNS neurons
CD169
Aka sialoadhesin
Macrophage-restricted cellular interaction molecule that binds sialylated ligands
Highly expressed on macrophages in chronically inflamed tissues, such as rheumatoid synovium and atherosclerotic plaques
Positive staining (normal): macrophages (all sites but microglia)
Negative staining: microglia
CD170
Aka Sialic acid binding IG-like LECtin 5 (SIGLEC5)
May function in cell-cell interaction
Positive staining (normal): neutrophils
CD171
Aka L1
Adhesion molecule required for normal neurohistogenesis
Mutations cause CRASH (Corpus callosum hypoplasia/agenesis, Retardation, Aphasia, Spastic paraplegia/shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, co-stimulation of T-cell activation in vitro
Positive staining (normal): post-mitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes
CD172a
Aka SIRP alpha
Adhesion structure
CD173
Aka blood group H2
Marker of early hemaoiesis
Positive staining (normal): CD34+ hemopoietic progenitor cells
Negative staining: mature lymphocytes
CD174
Aka Lewis Y antigen
Marker of early hemaoiesis
Positive staining (normal): CD34+ hemopoietic progenitor cells
Negative staining: mature lymphocytes
CD175
Aka Tn
Simple mucin-type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
CD175s
Aka
Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
Presence associated with aggressive tumors
High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining (tumors): carcinomas
CD176
Aka Thomsen-Friedenreich (TF) oncofetal blood group antigen, galactose beta 1-3 N-acetylgalactosamine alpha
Occurs in colon cancer and colitis
CD177
Aka NB1 glycoprotein
Major immunogenic molecule of neutrophil membrane
Positive staining (normal): myeloid cells
CD178
Aka CD95 ligand, Fas ligand (FasL)
Important role in T cell mediated cytotoxicity; induces apoptosis in Fas-expressing target cells
Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas-expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
Fas-FasL binding triggers apoptosis in lymphocytes
Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
Positive staining (normal): activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
Positive staining (tumors): Reed-Sternberg cells of Hodgkin’s lymphoma (nodular sclerosis and mixed cellularity, AJSP 2001;25:388)
Micro images (Hum Path subscribers): benign tamoxifen-exposed postmenopausal endometrium
CD179a
Aka VpreB1
Associates non-covalently with CD179b to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
Positive staining (normal): preB cells
CD179b
Aka lambda-5
Associates non-covalently with CD179a to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
Mutations impair B cell development and cause agammaglobulinemia
Positive staining (normal): preB cells
CD180
Aka RP105
Regulates B cell recognition of lipopolysaccharide, a membrane constituent of gram-negative bacteria
Positive staining (normal): mantle zone and marginal zone B cells (strong), other B cells (weak/negative); peripheral blood monocytes, dendritic cells
CD181
No information available
CD182
No information available
CD183
Aka CXCR3
Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining (normal): T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hemopoietic progenitors
Negative staining: naïve T cells in peripheral blood
CD184
Aka CXCR4, Stromal cell Derived Factor 1 (SDF1)
Receptor for the CXC chemokine SDF-1
Also major HIV/SIV co-receptor (with CCR5/CD195)
Involved in B cell development, myelopoiesis, cardiac ventricular septum formation, blood vessel formation in GI tract, cerebellar granular cell development
Positive staining (normal): all mature blood cells, blood progenitor cells, endothelial and epithelial cells, astrocytes, neurons
CD185
No information available
CD190
No information available
CD191
No information available
CD192
No information available
CD193
No information available
CD194
No information available
CD195
Aka CCR5
Macrophage surface receptor and attachment site for HIV and SIV, with CXCR4 (CD184); works with CD4
Receptor for CD8 chemokines RANTES, MIP 1-alpha and MIP 1-beta.
CD196
No information available
CDw197
Aka CCR7
