CD127

Aka Interleukin 7 receptor
Positive staining (normal): B cell precursors, most T cells, monocytes
 

CDw128a

Aka Interleukin 8 receptor alpha subunit, CXCR1
Chemokine receptor, powerful neutrophil chemotactic factor
Positive staining (normal): neutrophils, basophils, T cell subset, monocytes, keratinocytes
 

CDw128b

Aka Interleukin 8 receptor beta subunit, CXCR2
Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
Binds multiple CXC chemokines including IL-8
Positive staining (normal): mature granulocytes, projection neurons, neuroendocrine cells (various)
Positive staining (tumors): carcinoids, atypical carcinoids, metastatic carcinoids, pituitary adenomas, pheochromocytomas, medullary carcinomas
Negative staining: small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma
 

CD129

Reserved for Interleukin 9 receptor
 

CD130

Aka gp 130
Required for transducing biological activities of interleukin-6, interleukin-11, leukemia inhibitory factor, ciliary neurotrophic factor, oncostatin M, and cardiotrophin-1
In human, IL-6 and oncostatin M dependent activation of gp130 are involved in multiple myeloma
Positive staining (normal): almost all cell types (low levels)
 

CDw131

Aka common beta subunit
Does not bind any cytokine by itself, but is a component of the high affinity IL-3, GM-CSF and IL-5 receptors
Defective CDw131 is associated with protein alveolar proteinosis
Positive staining (normal): myeloid (early and mature), early B cells
 

CD132

Aka common cytokine receptor gamma chain - receptor for IL-2, IL-4, IL-7, IL-9 and IL-15
Mutation in humans causes X-linked severe combined immunodeficiency (no T cells, no NK cells)
CD132 is a target molecule for gene therapy for X-SCID
Positive staining (normal): T cells, B cells, NK cells, monocytes/macrophages, neutrophils
 

CD133

Aka prominin-like 1, AC 133
Alternative to CD34 in selecting hemopoietic stem and progenitor cells for transplantation studies
Localized to microvilli and other plasma membrane protrusions
Positive staining (normal): CD34 bright hemopoietic stem and progenitor cells, neural and endothelial stem cells, other primitive cells such as retina, villous and extravillous cytotrophoblast, syncytiotrophoblast
Positive staining (tumors): retinoblastoma, hemangioblasts, developing epithelium
Negative staining: adult epithelial tissue, villous stroma
 

CD134

Aka tax-transcriptionally activated glycoprotein 1 receptor, OX40 antigen, lymphoid activation antigen
 

CD135

Aka FMS-like tyrosine kinase 3, flt3
Growth factor receptor for early hemopoietic progenitors
Positive staining (normal): multipotential, myelomonocytic, and primitive B cell progenitors
Positive staining (tumors): most AML, ALL and CML
 

CDw136

Aka macrophage stimulating protein receptor, msp receptor
May regulate ciliary beat frequency in epithelial cells
Positive staining (normal): skin, kidney, lung, liver, intestine, and colon
 

CDw137

Costimulator of T cell proliferation
Positive staining (normal): T cells, especially CD45RA and CD45R0; also B cells, monocytes, epithelial cells
 

CD138

Aka heparan sulfate proteoglycan, syndecan-1
Mediates cell adhesion, growth factors; associated with late stage of B cell differentiation
Integral membrane protein is a receptor for extracellular matrix
Loss of CD138 expression is associated with tumor aggressiveness in squamous cell carcinoma (SCC) of head and neck and larynx; levels also reduced in invasive SCC but not in SCC-in situ
Interpretation: membranous staining
Positive staining (normal): B cell precursors, plasma cells, stratified squamous epithelium
Positive staining (tumors): keratoacanthoma, myeloma, primary effusion lymphoma, pyothorax associated lymphoma
Negative staining: mature B cells, lymphomas (even plasmacytoid lymphomas)
Micro images: plasma cells in Rosai-Dorfman disease
Micro images (AJSP subscribers): primary effusion lymphoma (figure C)
Micro images (Hum Path subscribers): primary effusion lymphoma (figure E)
Micro images (Mod Path subscribers): keratoacanthoma #1 (figure B), #2 (figure B), invasive squamous cell carcinoma
References: Mod Path 2002;15:45; AJSP 2002;26:1363
 

CD139

Positive staining (normal): B cells, monocytes, granulocytes, erythrocytes (weak), dendritic cells, glomeruli
Negative staining: T cells
 

CD140a

Aka alpha platelet derived growth factor receptor
 

CD140b

Aka beta platelet derived growth factor receptor
 

CD141

Aka thrombomodulin
75kD transmembrane glycoprotein and cofactor for the thrombin-mediated activation of protein C
Marker of mesotheliomas, endothelial cells and coagulation factor
Important fibrinolytic inhibitor, as it decreases the activation of plasminogen to plasmin
Critical for activation of protein C and initiation of the protein C anticoagulant pathway
Plasma CD141 levels are associated with endothelial damage
Interpretation: membranous staining pattern, often focal (cylasmic staining may be artifactual)
Uses:
Mesothelioma vs. lung adenocarcinoma: 64% sensitive, 95% specific for mesotheliomas, but must exclude vasculature; often membranous staining of periphery with isolated papilla; negative staining in sarcomatoid mesotheliomas; considered to have a “secondary” role as other markers are better, Hum Path 2002;33:953
Urothelial carcinomas (positive) vs. renal cell, prostate, endometrial or colonic carcinomas, AJSP 2001;25:1380
Squamous cell carcinomas (positive), AJCP 1998;110:385, AJSP 2003;27:150
Positive staining (normal): endothelial cells, megakaryocytes, keratinocytes, mesothelial cells, monocytes, neutrophils, platelets, smooth muscle cells, syncytiotrophoblasts, synovial lining cells, urothelium
Positive staining (tumors): mesothelioma (epithelioid), squamous cell carcinomas, trophoblastic tumors, urothelial carcinomas, vascular tumors (including angiosarcoma), synovial sarcoma (diffusely positive in 10%, AJSP 2001;25:610)
Negative staining: adenocarcinoma of colon, endometrium, kidney, lung (usually), prostate; sarcomatoid mesothelioma,
Micro images (AJSP subscribers): lung squamous cell carcinoma, lung adenocarcinoma, mesothelioma (figure 1B)
 

CD142

Aka coagulation Factor III, thromboplastin, tissue factor
Major initiator of clotting in normal hemostasis and many thrombotic diseases, via complex with factor VIIa
Also binds zymogen factor VII, the inactive precursor form; once bound, a variety of serine proteases rapidly activate factor VII to VIIa via limited proteolysis
Normally absent from all cells in direct contact with plasma
Positive staining (normal): epidermal keratinocytes, glomerular epithelial cells and various other epithelia, adventitial cells of blood vessels, astrocytes, myocardium, Schwann cells, stromal cells of liver, pancreas, spleen and thyroid
 

CD143

Aka angiotensin-converting enzyme, ACE, peptidyl dipeptidase A
Involved in metabolism of angiotensin II and bradykinin; also cleaves substance P and LH-RH
Patients with high activity have DD genotype, associated with MI, strokes, diabetic nephropathy
Necessary for spermatozoa to bind to egg and associated with better penetration of egg
Positive staining (normal): endothelial cells of small/medium arteries, lung capillary endothelium, proximal renal tubule brush borders, basal ganglia neuropil, granulosa cells, Leydig cells, variable on other cells
 

CD144

Endothelial-specific cadherin localized at intercellular junctions
Aka vascular endothelial-cadherin precursor, VE-cadherin, cadherin 5
Cadherins are cell adhesion proteins that preferentially interact with themselves in a homophilic manner in connecting cells, thus contributing to the sorting of heterogeneous cell types
Positive staining (normal): endothelial cells, brain
 

CDw145

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