I. Basic research for reproductive regulation.
1. Study on gene expression and regulation of spermatogenesis---New gene screen, cloning , structure and founctional regulation during spermatogenesis.
2. Basic research on the mechanism of fertilization,
1) Key molecular regulation of acrosomal reaction.
2) Regulated mechanism of sperm factor to oocyte activiation.
3) Signal transduction in the recognization between sperm and oocyte and regulation in early embryonic development.
3. Study on molecular mechanism of implantation,
1) Cloning and founctional studies of genes critical to implantation.
2) Molecular mechanism of controlling the switch on and off of implantation “window” and regulation cascade of implantation process.
3) Molecular basis of controlling invasion of trophoblasts.
II. Research of etiologic mechanism of major birth defects.
1. Research of etiologic mechanism of congenital cardiac defects and cloning of congenital cardiac defects related gene.
2. Establishing a biologic information bank of birth defects with Chinese characteristics.
