Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor

Myxoma virus (MV) is a rabbit specific poxvirus that causes a lethal disease called myxomatosis in European rabbits (Oryctolagus cuniculus) (1). MV encodes a wide complement of immune evasion molecules, including an ankyrin-repeat host range protein called M-T5 (2, 3). M-T5 acts to prevent apoptosis during infection of rabbit T lymphocytes and is a virulence factor for disease progression in infected rabbits (4).  Johnston, J. B., Wang, G., Barrett, J. W., Nazarian, S. H., Colvill, K., Moran, M. & McFadden, G. have recently demonstrated that M-T5 also acts to protect MV-infected cells from cell cycle arrest through interactions with cullin-1, which is involved in regulation of p27 through ubiquitin-dependent proteasome degradation pathway .

Origin article：

Gen Wang, John W. Barrett, Marianne Stanford, Steven J. Werden, James B. Johnston, Xiujuan Gao, Mei Sun, Jin Q. Cheng, and Grant McFadden. Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor PNAS 2006 103: 4640-4645; published online before print March 14 2006, 10.1073/pnas.0509341103 
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