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2',5'-oligoadenylate synthetase

<enzyme> An enzyme that catalyses the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (rnase l) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

Registry number: EC 2.7.7.-

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