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ciliary neurotrophic factor

<growth factor> Neurotrophic factor originally characterised as a survival factor for chick ciliary neurons in vitro.

Subsequently shown to promote the survival of a variety of other neuronal cell types and to promote the differentiation of bipotential O2A progenitor cells to type 2 astrocytes in vitro.

Molecular cloning and expression studies indicate that CNTF is a cytosolic protein. Developmental expression and regional distribution studies show that, unlike NGF, CNTF is not a target derived neurotrophic factor.


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