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CD4
<immunology> 55-
kD glycoproteins originally defined as
differentiation antigens on
T-lymphocytes, but also found on other
cells including monocytes/macrophages.
CD4 antigens are
members of the
immunoglobulin supergene family and are implicated as associative recognition
elements in
MHC (
major histocompatibility complex)
class II-restricted
immune responses. On
T-lymphocytes they
define the helper/inducer subset. Cd4
antigens also
serve as
HIV receptors,
binding directly to the
envelope protein gp120 on HIV.
The protein structure on the surface of a human cell that allows HIV to attach, enter, and thus infect a cell. CD4 receptors are present on CD4 cells (helper T-cells), macrophages and dendritic cells, among others. Normally, CD4 acts as an accessory molecule, forming part of larger structures (such as the T-cell receptor) through which Tcells and other cells signal each other.
Previous:
CD19,
CD2,
CD20,
CD26,
CD27,
CD28,
CD29,
CD3,
CD30,
CD31,
CD34,
CD36Next:
CD40,
CD44,
CD45,
CD45 phosphatase,
CD4/CD8 count,
CD4:CD8 ratio
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