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& genomics Bioinformatics
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sciences Cell biology
glossary Chemoinformatics
glossary Chromatography
& electrophoresis glossary Clinical
genomics glossary Computers &
computing glossary Databases
& software directory Drug (and device and diagnostics) approvals
& clinical trials Drug
discovery & development glossary Expression
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overview Intellectual property glossary Journal links Maps,
genomic & genetic glossary Mass
spectrometry glossary Microarrays
glossary Miniaturization
glossary Model
& other organisms glossary Molecular
modeling glossary Nomenclature,
genes, proteins & species NMR
& x-ray crystallography glossary -Omes &
-omics glossar> Pharmaceutical
biology glossary Pharmacogenomics
glossary Protein
structure glossary Proteins
glossary Proteomics
glossary Research glossary Sequences,
DNA & beyond glossary Sequencing
glossary Structural
genomics glossary Technologies
& instrumentation glossary Last revised March 8,
2001
Alpha index by categories Roger Brent said in his opening
remarks for the 2000 After the Genome meeting in Jackson Hole Wyoming "current
efforts to come to grips with genomic information often resemble computer-savvy
library science, where the most important issues concern categories,
classification schemes and information retrieval…What we would actually
like to achieve, however, is a predictive understanding of biological
function. The goal here is a true computational biology that will be able
to make functional predictions from available genomic data [italics added]
http://www.atgx.org/info_gruber.html Algorithms & data management glossary 3D QSAR ab initio calculations In-depth ab initio quantum mechanical methods In-depth algorithm artificial intelligence In-depth artificial neural nets In-depth Bayesian inference algorithms In-depth ClogP values In-depth cluster analysis Comparative Molecular Field Analysis CoMFA In-depth conformational analysis In-depth correlation analysis In-depth decision trees In-depth experimental design In-depth expert systems In-depth factorial design In-depth fuzzy In-depth fuzzy logic In-depth genetic algorithm GA heuristic heuristic algorithm Hidden Markov Models HMM knowledge based systems In-depth memory-mapped data structures In-depth molecular pattern recognition In-depth Monte Carlo techniques In-depth mosaic plots In-depth multivariate statistics In-depth neural networks parsing partial least squares In-depth pattern recognition PR principal components analysis PCA In-depth QSAR Quantitative Structure-Activity Relationship quantum chemical calculations In-depth receptor mapping In-depth recursive partitioning In-depth regression analysis SIMCA Simple Classification Analysis, Soft Independent Modeling of
Class Analogy In-depth SPC Structure Property Correlations In-depth semi-empirical methods In-depth sequencing algorithm simulated annealing SA In-depth training set visualization visualisation tools Assays, labels, signaling and detection
glossary assay attomole avidin In-depth bioassay biosensor biosensor-electrochemical competitive immunoassay detection detector technologies direct detection femtomole fluorescence fluorophore Green Fluorescent Protein GFP homogeneous assay immunoassay immunometric assay immunohistochemistry In-depth label luminescence nanoparticle picomole quantum dot reagents sandwich assay In-depth sensitivity specificity ultrasensitive yocotomole zeptomole In-depth Assays, labels, signaling &
detection glossary include bioluminescence, biotin, biotinylation,
chemiexcitation, chemiluminescence, colorimetry, electrochemistry, FRET Fluorescence Resonance Energy Transfer, fluorescence polarization, LIF
Laser Induced Fluorescence, luminometer, quenching, photon, reactant,
reagents, scintillation, streptavidin, Surface Plasmon Resonance SPR, target
labelling, tracer. Basic genetics (& genomics) weblinks & overview adenine A Bacterial Artificial Chromosome BAC base base pair bp biotechnology cloning vector cytosine C double helix gene genetic code guanine G Mendelian disorders Mendelian genetics recombinant DNA technology recombination thymine T uracil vector vector, cloning vector, genetic Bioinformatics glossary annotation of databases annotation of genes bioinformatics computational genetics curated databases databases EBI European Bioinformatics Institute Ensembl Gene Ontology TM
GO integrated databases interoperability NCBI National Center for Biotechnology
Information non-redundant databases proprietary databases standards structural bioinformatics XML eXtensible Markup Language In-depth bioinformatics glossary include Biomedical Information
Science and Technology Initiative BISTI; BISTI Consortium, BSML Bioinformatic
Sequence Markup Language; biocorba.org, biojava.org, Bio-ontology
Standards Group, bioperl.org, biopython.org, bioWidget Consortium,
bioxml.org, CORBA Common Object Request Broker Architecture,
computational biology; Data Model Standards Group, Genome Annotation
Data Warehouse; LSR Life Sciences Research group; metadata, OMG Object
Management Group; ontology. Biomolecules glossary biomolecules biopolymers carbohydrates DNA Dalton glycans glycoconjugates macromolecular systems macromolecules micromolecules nucleic acids oligosaccharides peptides polymers polysaccharides protein proteoglycans sacccharides xenobiotic Business of the life sciences glossary alliances alliance networks anti-trust applied research basic research CORDIS Community Research and Development Information Service In-depth CRADA Cooperative Research and Development Agreement In-depth collaboration consortia, consortium database subscription deal types In-depth development discovery rights drug discovery and development deals database emerging companies In-depth equity investment extension of agreement for-profit genomics Framework Programme on Cooperative Research and Technological Development
and Demonstration; Fifth Framework Programme In-depth funding of genomic research genomic deals genomic technologies In-depth harmonization high tech hypercompetitive intellectual property resources joint ventures licensing licensing of a drug target life sciences industry mergers and acquisitions mezzanine financing NAICS North American Industry Classification System In-depth NAPCS North American Product Classification System In-depth NCRA National Cooperative Research Act NCRPA National Cooperative Research and Production Act non-genomic technologies In-depth PIPEs Private Investments in Public Equity partial acquisition partnerships partnership structures patent acquisition In-depth patent systems pharmaceutical industry platform companies platform strategy pre-competitive R&D R&D research and development RJV Research Joint Ventures risk management royalty stacking SBIR Small Business Innovation Research In-depth STTR Small Business Technology Transfer In-depth SIC Standard Industrial Classification codes In-depth SME Small and Medium sized Enterprise In-depth spin-offs start-ups strategic alliances TRAs Technology Research Associations IN-depth technology consortium, technology consortia technology transfer technology service agreement In-depth tender offers termination of agreement In-depth venture capital Cell biology glossary apoptosis autosome CHO cells Chinese Hamster Ovary cells
In-depth cell, cells In-depth cell lines In-depth cell adhesion cell cycle cell differentiation centromeres In-depth chromatin In-depth chromosome clone clone bank cloning cytoplasm In-depth cytoskeleton In-depth developmental biology In-depth differentiation – cell diploid ES Embryonic Stem cells euchromatic In-depth euchromatin In-depth eukaryotes eukaryotic cells extracellular matrix In-depth fusion In-depth fusion, cell In-depth gamete germ cells Golgi Apparatus In-depth haploid hematopoietic stem cells heterochromatic In-depth histones In-depth host host-vector system hybridoma library library-genomic lysis In-depth macrophages In-depth meiosis In-depth metabolism metabolite mitochondria mitosis In-depth nucleus In-depth organelles plasmid ploidy prokaryote In-depth pronucleus In-depth ribosomes second messenger second messenger systems somatic cell somatic cell hybridization In-depth spliceosomes stem cells T cells telomere Chemoinformatics glossary CML Chemical Markup Language chemical information system In-depth chemoinformatics, chemi-informatics, chemiinformatics chemometrics In-depth computational chemistry In-depth data mining data mining, genomic GUI Graphical User interface In-depth in silico Lipinski's rules of five "plug and play" systems In-depth rules of five "silo systems" In-depth Structure Activity Relationship SAR. virtual library virtual screening Chromatography & electrophoresis glossary 2D gel electrophoresis affinity chromatography CE-MS Capillary Electrophoresis-Mass Spectrometry CIEF Capillary electrophoresis IsoElectric Focusing capillary array Capillary Electrophoresis CE capillary gel electrophoresis carrier ampholytes chromatography DGGE Denaturing Gradient Gel Electrophoresis Edman degradation electrophoresis frontal affinity chromatography gel electrophoresis HPLC High Performance Liquid Chromatography IEF IsoElectric Focusing IPG Immobilized pH Gradient IGP-DALT ISO-DALT immobilized pH gradient shift immobilized pH gradient strips, very narrow range in gel protein digestion isoelectric point liquid chromatography LC NEPHGE non-Equilibrium pH Gradient Gel Electrophoresis non-denaturing gel electrophoresis pI PAGE polyAcrylamide Gel Electrophoresis protein affinity chromatography SDS-PAGE Sodium Dodecyl Sulfate PolyAcrylamide Gel Electrophoresis zoom gels Clinical genomics glossary autosomal dominant inheritance autosomal recessive inheritance cancer genomics clinical genomics clinical sensitivity clinical trials comparative data mining compound heterozygosity diagnosis disease intervention diseases drug familial cancer family history gene therapy genetics genetic test genetic testing germline mutation hereditary cancer heterozygous homozygous LOH Loss of Heterozygosity morbidity, compressing mortality, reducing predictive data mining predictive testing predisposition, genetic presymptomatic test somatic cells sporadic cancer susceptibility time delay data mining trends based data mining In-depth Clinical Genomics
definitions include analytical sensitivity, analytical specificity,
carrier testing, clinical sensitivity, clinical specificity, drug, genetic
counseling, genetic screening, new born screening, predictive testing,
predisposition test, preimplantation diagnosis, prenatal diagnosis, prognosis,
risk communication. Databases & software directory available by email. Request
from mchitty@healthtech.com 3Dee Database of Protein Domain Definitions AA Index, Amino Acid Index ALFRED Allele Frequency Database ASTRAL ASDB AceDB allgenes.org BIND Biomolecular Interaction Network Database BLOCKS BODYMAP BRITE Biomolecular Relations in Information Transmission and Expression Berkeley Drosophila Genome Project BDGP Biochemical Pathways (Boehringer Mannheim) BioMasRes cDNA relational databases CATH Class Architecture Topology Homology CCAP Cancer Chromosome Aberration Project CGAP Cancer Genome Anatomy Project COG Clusters of Orthologous Groups of Proteins CSNDB Cell Signaling Networks Data Base C. elegans WWW Server C. elegans Gene Knockout Consortium Celera Genomic Reference Database Celera SNP Reference Database Clone Registry Conserved Domain Database CDD dbEST dbGSS dbSNP dbSTS DATABANKS DBcat DataBase Catalog DDBJ DNA DataBank of Japan DBGET/LinkDB DIP Database of Interacting Proteins DNA-Gene Mutational databases DOTS Database of Transcribed Sequences DPI Interact DSSP Dali Database of Ribosomal Cross Links Decoys R’ Us DeltaBase Discover Ease Drosophila melanogaster genome EGAD EID Exon Intron Database EMBL European Molecular Biology Lab ENZYME EPD Eukaryotic Promoter Database Entrez Entrez Genomes Eukaryotic Organelles Home Page ExInt ExPASy Expert Protein Analysis System Express DB FSSP Fold classification based on Structure-Structure alignment of
Proteins FlyBase Flyview GDB Genome Data Base GENOTK GGEG Global Gene Expression Group GOBASE Organelle Genome Database GOLD Genomes OnLine Database GSDB Genome Sequence DataBase GXD Gene Expression Database GadFly GenBank GeneCards Gene Census System Gene Express Gene Expression Omnibus GEO Gene Map of the Human Genome Gene Scape Gene Solutions GeneX Genetic Annotation Index GAI Genome Analysis Pipeline Genome Catalog Genome Channel Genome MOT Genome MOnitoring Table German Human cDNA Project HGBASE Human Genic Bi-Allelic Sequence Database HGMD Human Gene Mutation Database HOMOLOGENE HSSP Homology-derived Secondary Structure of Proteins HuGE Human Gene Expression Index HUGE Human Unidentified Gene Encoded Large Proteins Hits Human Gene Index Human Genome Sequencing Human Mouse Homology Maps Human SNP Database Human Tumor Gene Index (hTGI) CGAP IMAGE Integrated Molecular Analysis of Genomes and their Expression ISSD Interactive Fly Interfunctional Proteomics Data Base KEGG Kyoto Encyclopedia of Genes and Genomes KMDB Kabat Database of sequences of proteins of immunological interest Klotho LIGAND LPFC Library of Protein Family Cores Life Seq LocusLink Locus Specific Mutation Databases MAGEST MAGPIE Multipurpose Automated Genome Project Investigation Environment MGD Mouse Genome Informatics MIPS Munich Information Center for Protein Sequences MIRAGE Molecular Informatics Resource for the Analysis of Gene Expression MITOMAP MKMD Mouse Knockout Mutation Database MMDB Molecular Modeling DataBase MODBASE MOT See Genome MOT Malaria Genetics and Genomics Mammalian Gene Collection Medline, Medlars Microbial Genomes Sequencing Projects Mitelman Chromosomal Aberration Summary Molecular Probe Data Base MPDB Molecular Profiling, CGAP Mouse Atlas and Gene Expression Database Mouse Genome Sequencing Mouse Tumor Gene Index NCBI RH {radiation hybrid] Map NDB Nucleic Acids Database NIH Rat Genomics and Genetics OMIA Online Mendelian Inheritance in Animals OMIM Online Mendelian Inheritance in Man OWL OmniBank PDB Protein Data Bank PEDB PIR Protein Information Resource PROW Protein Resources on the Web PUMA, Phylogeny of Unicellular organisms Path DB Pfam Presage Prints ProClass ProDom ProSite Protein Sequence Database SEE PIR proWeb project ProtFam PubMed, PubMed Central PubRef RESID RGD Rat Genome Database (Univ. Wisconsin) Rat Genome Data (Jackson Lab) Rat Genome Database (Sweden) RatMap Ref Seq Retrovirus Resources SAGE Analysis SAGE map SBASE SCOP Structural Classification of Proteins SGD Saccharomyces Genome Database, SGD Worm-Yeast Protein Comparison SPAD Signaling Pathway Database SRS Sequence Retrieval System SWISS-PROT SWISS 2D PAGE Saccharomyces Genome Deletion Project Single Nucleotide Polymorphisms in the Human Genome WWW TRANSFAC TRIPLES TrEMBL Taxonomy Transpath Transterm UniGene Vector DB VecScreen WIT2 What is There Worm Chip Directory Worm PD XREF db YPD Yeast Proteome Database ZFIN Zebrafish Information Network Software includes BEAUTY, BLAST, CLUSTALW, DBGET, DBSearching, browsing
and analysis tools, Dbsolve, Electronic PCR, Fasta, Gene Identification
Software Sites GRAIL, Gapped BLAST, MedMiner, ORF Finder, PHRED, PHRAP,
PSA Protein Structure Predicter Server, PredictProtein Server, Proteomic
tools, PSI-BLAST, SMART (Simple Modular Architecture Research Tool), SWISS-Model,
SYSTERS, Sequin, VAST, Yeast Tools, WWW Promoter Scan Drug discovery & development glossary aliquot In-depth aptamer array synthesis in-depth autosampler In-depth bead binning In-depth building block In-depth chemical genetics chemical genomics chemogenomics cleavage In-depth cluster In-depth combichem combinatorial In-depth combinatorial chemistry combinatorial library combinatorial synthesis crosslinking In-depth Dalton de novo design In-depth deconvolute In-depth dendrimer In-depth directed library In-depth diversity drug design drug development drug discovery drug discovery pipeline drug targeting druggable focused library In-depth fully combinatorial In-depth gel phase In-depth HTS High Throughput Screening high throughput organic synthesis hit in situ scaffold formation In-depth iterative deconvolution In-depth LIMS Laboratory Information Management
Systems lead discovery lead generation lead optimization lead validation ligand design linker In-depth low hanging fruit MPS Multiple Parallel Synthesis In-depth massively parallel In-depth me too drug In-depth medicinal chemistry In-depth member In-depth microtiter plate, microtitre plate molecular design molecular diversity. molecular mimicry In-depth monomer IN-depth orthogonality In-depth parallel synthesis In-depth peptidomimetic In-depth pharmacophore generation In-depth pool In-depth pool/split In-depth preformed scaffold In-depth privileged structures In-depth property space In-depth random library In-depth rational drug design recognition site In-depth resin In-depth residue In-depth robotic system robotics robust SELEX Systematic Evolution of Ligands
by Exponential Enrichment SPE Solid Phase Extraction In-depth sample preparation scaffold scalable screening small molecules solid phase extraction SPE In-depth solid support In-depth soluble support In-depth sort and combine In-depth spatially addressable stochastic In-depth structure activity relationship SAR structure-based design sub-library In-depth target target validation template tether In-depth ultra high-throughput screening UHTS unbiased library In-depth Expression glossary clinical profiling of gene expression conditional gene expression co-regulation In-depth diauxic shift In-depth differential display differential gene expression downregulation In-depth EVGs Expression Verified Genes expression expression profiling expression profiling sensitivity expression proteomics expression technologies GEML Gene Expression Markup Language gene expression gene expression analysis gene expression arrays gene expression profiling genetic profiling genome expression genomic profiling global gene expression guilt by association method In-depth influence based data mining mRNA expression molecular profile overexpression/underexpression In-depth pathways protein expression protein expression profiling RNA expression reverse transcriptases In-depth reverse transcription SAGE Serial Analysis of Gene Expression subtraction cloning TOGA Total Gene Expression Analysis tissue profiling transcript transcript expression transcript imaging transcript map transcript profiling transcription transcription factors transcription machinery transcriptional fingerprint underexpression upregulation whole genome expression Functional genomics glossary bacteriophage In-depth Biopathways Consortium cenancestor In-depth chemical mutagenesis comparative genomics Cre-lox In-depth deductive genomics In-depth embryonic lethal trait embryonic stem cells ES forward genetics functional genomics gene disruption gene function genetic programs genome function homolog, homologous, homologue homology insertional mutagenesis ion channels In-depth knockdown knockin knockout knockout, conditional lateral genomics In-depth molecular networks molecular systematics mutagenesis networks ortholog, orthologue paralog, paralogue pathways phage In-depth phage display phylogenetic profile method phylogenetic tree phylogenomics positional cloning retrovirus In-depth reverse genetics saturation mutagenesis signal transduction similarity site-directed mutagenesis transposon vector vector, cloning vector, genetic xenology Gene amplification & PCR glossary absolute quantification amplicon amplification amplimer cPCR competitive PCR end-point FISH Fluorescence In Situ Hybridization gene amplification hybridization in situ hybridization isothermal molecular beacons multiplex nucleic acid amplification and detection PCR Polymerase Chain Reaction polymerase In-depth primer extension primers probes quantitative gene amplification quantitative PCR quantitative RT-PCR RNA amplification RT-PCR Reverse Transcriptase PCR real time relative quantification relative quantitative RT-PCR reverse transcriptases semi-quantitative Taq polymerase target In-depth Gene amplification & PCR
glossary include ASO probe Allele Specific Oligo, anneal, capture probe,
kinetic RT-PCR, ligase chain reaction LCR, microtransponder, nested PCR,
non-competitive RT-PCR, PNA Peptide Nucleic Acid, PNA probes, Random Amplified Polymorphic
DNA technique RAPD. Gene definitions candidate gene In-depth cis- In-depth cis-trans test In-depth gene gene (human) alternative splicing epigenetics gene family gene imprinting gene product gene silencing gene subfamily housekeeping genes hypothetical genes immunoglobulin genes In-depth immediate-early genes In-depth jumping genes In-depth lethal genes localize locus, loci luxury genes In-depth mitochondrial genes non-nuclear genes In-depth nuclear genes In-depth ORF Open Reading Frame oncogenes In-depth operons In-depth organelle genes In-depth orphan genes pleiotropic genes In-depth polycistronic In-depth polygene In-depth processed genes In-depth promiscuous genes In-depth pseudogenes In-depth putative genes quantitative genes In-depth rRNA genes In-depth regulator genes In-depth regulatory genes In-depth regulatory region In-depth regulon In-depth reporter genes In-depth split genes In-depth structural genes In-depth superfamily suppressor genes In-depth syntenic genes In-depth synteny In-depth transposons tumor suppressor genes In-depth Genetic variations glossary alleles association studies biomarkers deletions In-depth direct approach In-depth enhancement In-depth epigenetic genetic architecture Hardy-Weinberg law In-depth human genome epidemiology linkage analysis In-depth markers markers biological markers, DNA markers, genetic molecular variation multifactorial multigenic In-depth mutation mutation rate oligogenic In-depth pleiotropism, pleiotropy In-depth point mutations In-depth polymorphisms population genetics In-depth positional candidates In-depth random genome-wide association studies
In-depth SNP Single Nucleotide Polymorphism The SNP Consortium TSC scan, genome scanning scoring variants wild-type In-depth Genetic variations glossary include aggregate, anonymous
SNPs, bi-allelic, cSNPs, CEPH Centre d’Etude du Polymorphism Humaine, candidate
gene approach, candidate SNP, correlation studies, DHPLC Denaturing HPLC,
DNA fingerprinting, DNA footprinting, DNA ligase enzymes, diallelic, duplications,
endonucleases, epitasis, frameshift mutation, functional cloning, Genetic
Annotation Initiative, genetic drift, genetic recombination, haplotype,
idiomorphism, indels, insertion, leaky mutation, linkage, linkage disequilibrium,
localize, loss-of-function mutation, microsatellite markers, microsatellite
repeat polymorphism, minisatellite repeats, negative selection, neutral
mutations, null mutations, pSNPs, phenocopy rSNPs, RFLP Restriction Fragment
Length Polymorphisms, recombinant, recombination, regional scanning, restriction
enzymes, SSCP Single Strand Conformational Polymorphisms, SSEP Single Strand
Electrophoretic Polymorphisms, STR Short Tandem Repeats, STSs Sequence
Tagged Sites, satellite, segregation, slightly deleterious alleles, suppression,
synonymous SNP, tandem repeats, tri-allelic. Genomics glossary applied genomics biochemical genomics chemical genomics In-depth complex complex diseases complex phenotypes complex traits DDBJ DNA Data Bank of Japan DOE Department of Energy In-depth EMBL European Molecular Biology Lab GenBank genetic architecture genome Genome Analysis Pipeline In-depth Genome Catalog In-depth Genome Channel In-depth genomic DNA genomics genotype HUGO Human Genome Organization Human Genome Project HGP Joint Genome Initiative JGI In-depth lateral genomics Mendelian disorders microbial genomics NHGRI National Human Genome Research Institute penetrance phenotype polygenic post-genomic RIKEN whole genome Genomic applications overview BLAST druggable functional genomics genetic testing genomic deals genomics Human Genome Project Human Proteome Project low hanging fruit Mendelian genetics new paradigm paradigm shift pharmacogenomics post-genomic proteomics structural genomics transcriptomics Genomic biology overview apoptosis biomolecules biotechnology combinatorial biology expression gene gene nomenclature, human genetic maps hypothetical protein model organisms protein structure SNP Single Nucleotide Polymorphism "working draft" Human Genome sequence Imaging glossary 2 photon excitation 2 photon microscopy atomic force microscopy CCD Charged coupled device CCD camera chemical force microscopy circular dichroism spectroscopy confocal microscopy detector technologies electron microscopy fluorescence microscopy fluorescence spectrometry image analysis - microarrays ion microscopy laser Laser Fluorescence Microscopy LFM MRI Magnetic Resonance Imaging MRS Magnetic Resonance Spectroscopy magnetic resonance force microscopy Near Infrared Spectrometry NIR non-linear optics photons Raman spectrum analysis SEM scanning electron microscopy STEM scanning transmission electron microscopy STM Scanning Tunneling Microscopy scanning probe microscopy scanning technology scanning tunneling microscopy TEM transmission electron microscopy transcript imaging Informatics overview 3D-QSAR bioinformatics biomedical computing (biomedical information
science & technology) bottom-up chemoinformatics clinical informatics complexity DNA computing databases data mining federated databases high performance computing hypothesis driven research in silico informatics information overload interoperability metadata middleware molecular computing molecular modeling ontology peta petaflop problem-driven research quantum computing research informatics schema, schemata self-organization standards supercomputer teraFlop Tflop top-down web XML eXtensible Markup Language Maps genomic & genetic glossary bottom-up cDNA maps cell mapping chromosome mapping chromosomal maps clone based maps comparative genome mapping cosmid maps contig mapping contig maps cytogenetic maps DNA maps ESTs epitope mapping expression mapping gene map gene mapping genetic linkage map genetic mapping genetic maps genome control maps high density maps high-resolution genetic maps high-resolution physical mapping linkage disequilibrium linkage maps locus macrorestriction map mapping microsatellite markers nucleotide mapping peptide mapping physical maps positional cloning Protein Expression Mapping PEM protein interaction mapping protein linkage maps RFLP Radiation Hybrid (RH) maps receptor mapping resolution restriction mapping SNP maps STS tandem repeats top-down transcript maps Mass spectrometry glossary 2D CE-IMLS 2D Capillary Electrophoresis
with Inverted Mass Ladder Sequencing, CE-MS Capillary electrophoresis Mass
Spectrometry, CIEF Capillary electrophoresis IsoElectric Focusing; Collision
Induced Dissociation CID; ESI ElectroSpray Ionization, ESI-MS-MS ElectroSpray
tandem mass spectrometry, ESI-TOF ElectroSpray Ionization-Time-of-Flight,
ion trap mass spectrometry, LC/MS interfaces, LC/MS, MALDI Matrix Assisted
Laser Desorption Ionization, MALDI-TOF Matrix Assisted Laser Desorption
Ionization-Time of Flight mass spectrometry, MALDI-TOF-PMF Matrix Assisted
Laser Desorption Ionization-Time of Flight/ Peptide Mass Fingerprinting,
MS/MS scans, MS/MS/MS/, mass spectrometry, mass-to-charge ratio (m/z),
multiple mass spectrometry, nanoelectrospray-MS/MS, PMF Peptide Mass Fingerprinting,
Photon Induced Dissociation PID, quadrupole mass analyzer, quadrupole ion
trap, TOF Time-of-Flight mass spectrometer, tandem mass spectrometry, triple
quadrupole. Microarrays glossary antibody microarrays bead arrays, bead chips, bead microarrays biochips cell arrays, cell chips, cell microarrays DNA chips, DNA arrays, DNA microarrays detection methods gene arrays, gene microarrays GeneChip ® genome arrays genome chip genomic microarrays high density microarrays high density oligonucleotide arrays hybridization arrays in situ arrays LabChip ® lab-on-a-chip matrix solid state microarrays microchips microelectronic arrays micron oligonucleotide arrays, chips, microarrays,
microchips protein array, protein chip, protein microarray SNP chips small molecule microarrays spotted arrays tissue arrays, tissue chips, tissue microarrays validation - microarrays In-depth Microarrays glossary array technology; arrayed libraries, blotting; blotting, Northern;
blotting, Southern, blotting, Western; cDNA arrays, CCD, cell arrays, chips;
clone arrays; dot blots; exon arrays, filter arrays; Genosensor™ system;
glycochips, oligosaccharide arrays; gridded cDNA microarrays; inkjets;
laser; macroarrays, nylon; mask microspotting; peptide arrays; photolithography;
probe arrays; suspension arrays tiling arrays. Miniaturization glossary BioMEMS carbon nanotubes DNA diagnostics, miniaturization integrated microdevices (IM) MEMS MicroElectro Mechanical Systems microchemistry microfabrication microfluidics microinjection micromachining micron microTas microTotal Analysis System uTAS miniaturization nano- nanofabrication nanoparticles nanotechnology optical tweezers self-assembly uTAS Model & other organisms glossary animal models Arabadopsis brassica Caenorhabditis elegans, C. elegans,
worm Drosophila melanogaster, fly E. coli, Escheria coli model organisms mouse, Mus musculus murine mustard Rat,
Rattus Norvegicus, Saccharomyces cerevisiae, S. cerevisiae,
yeast transgenic Xenopus, frog zebrafish, Dario rerio. Molecular Modeling glossary ab initio gene prediction ab initio modeling ab initio quantum mechanical methods In-depth computational gene recognition computational modeling Computer Assisted Drug Design CADD Computer Assisted Molecular Design CAMD Computer Assisted molecular modeling CAMM decoys In-depth docking docking studies drug design dynamic programming energy function In-depth exon prediction force field In-depth gene identification gene prediction gene recognition gene structural components granularity homology model homology modeling in silico in silico screening molecular dynamics In-depth molecular graphics molecular mechanics In-depth molecular modeling molecular models molecular recognition ORF prediction protein structure prediction scoring methods semi-empirical methods In-depth semi-empirical quantum mechanical methods In-depth simulations structure analysis VRML Virtual Reality Modeling Language virtual library virtual screening NMR & X-ray crystallography bicelle, COSY Correlated Spectroscopy, chemical shift, cryogenic probe,
cryoprobe, crystallography, dephases, distance mapping, ESR Electron Spin
Resonance, FT NMR Fourier Transform NMR, flexible linkages, HMQC Heteronuclear
Multiple Quantum Correlation, HR-MAS High Resolution Magic Angle Spinning,
HSQC Heteronuclear Single Quantum Correlation, hyphenated techniques kD
kilo Dalton, LC- NMR, LC-MS-NMR, MAS Magic Angle Spinning, NOE Nuclear
Overhauser Effect, NOESY Nuclear Overhauser Enhancement and Exchange Spectroscopy,
NMR Nuclear Magnetic Resonance, NMR-biomolecular, pulse sequence, pulsed
field gradient, ROESY Rotating frame Overhauser Enhancement Spectroscopy,
SAR by NMR, STD-NMR Saturation Transfer Difference NMR, solid state, solution
state, spin diffusion, spin label, spin relaxation, spin-spin relaxation,
TOCSY Total Correlation Spectroscopy, X-ray crystallography, X-ray diffraction. Nomenclature carbohydrate nomenclature enzyme nomenclature gene nomenclature, human gene nomenclature, human mutations gene nomenclature- plants and animals) model organisms nomenclature protein nomenclature. -Omes & -Omics glossary biome biomics BioNome cellome cellomics epigenome epigenomics epigenotype glycome glycomics immunome immunome, cancer mmunomics metabolome metabolomics metabonome metabonomics morphome morphomics -ome -omes, integrating -omics operome project operomics phenome phenomics physiome physiomics regulomics resistome somatonome transcriptome transcriptomics. Pharmaceutical biology glossary affinity agonists antagonists antibody, antibodies antigens antisense molecule binding sites chiral chirality chromophore In-depth chromophore assisted laser inactivation DNA binding DNA vaccines enantiomer enzymes epitopes G-proteins In-depth G-protein coupled receptor GPCR In-depth G-protein coupled receptors, orphan In-depth hormones hybridomas ligands lock and key monoclonal antibodies, monoclonal antibody orphan receptors pharmacophores racemates receptors recognition sites recombinant DNA In-depth recombinant proteins In-depth recombinant therapeutics recombination, genetic In-depth substrate vaccines Pharmacogenomics glossary ADME ADME/Tox biopharmaceutics In-depth biotransformation In-depth drug metabolizing enzymes mechanisms of action mode of action pharmacogenetics pharmacogenomic technologies pharmacogenomics pharmacokinetics structural pharmacogenomics tox-chips toxicogenomics toxicokinetics Proteins glossary amino acids amino acid sequence glycosylation housekeeping proteins hypothetical protein luxury proteins peptides phosphorylation post-translational modifications post-translational protein processing primary structure protein expression protein, proteins protein sequence putative proteins secreted proteins In-depth Proteins glossary include amino terminus, basic proteins,
C-terminus, carboxyl terminus, checkpoint control proteins, co--immunoprecipitation,
co-precipitation, cross annotation, cytokines, denaturation, depletion,
directed protein evolution, factitious protein, fusion proteins (recombinant),
gatekeeper protein, heat shock proteins, hydrophobic proteins, immunoprecipitation,
molecular chaperones, N terminus, peptide library, peptide receptors, perturbagens,
prefractionation, protein synthesis, residue, sequential regulation, zinc
finger proteins. Protein structure glossary amino acid motif beamline conformation disordered proteins domain membrane proteins misfolding motif, amino acid protein conformation protein domain protein family, protein families protein folding protein motif protein sequence protein structure protein structure prediction protein structure, quaternary protein structure, secondary protein structure technologies protein structure, tertiary protein superfamily structure function of proteins synchrotrons In-depth Protein structure glossary includes aggregation,
amino terminus domain, carboxyl terminus domain, native state, peptide
library, peptide receptors, perturbagens, protein fold, sequential regulation. Proteomics glossary 2D gel electrophoresis chemical proteomics comparative proteomics DNA-protein interactions dissociator assays evolutionary homology functional proteomics Human Proteome Project interaction proteomics pharmacoproteomics phylogenetic profiles protein dynamics protein expression protein function protein-protein interactions proteome proteomics proteomics technologies reverse-two hybrid riboproteomics In-depth Rosetta stone method In-depth structural proteomics In-depth tissue proteomics toxicoproteomics yeast one hybrid yeast three hybrid yeast two hybrid Sequences, DNA & beyond 3' UTR In-depth 5' UTR In-depth alternative splicing amino acid sequence In-depth attenuator In-depth cDNA CDs In-depth carbohydrate sequence In-depth coding regions coding sequences codon complementary DNA cDNA DNA In-depth DNA synthesis In-depth EST Expressed Sequence Tag enhancer In-depth exons gene coding inteins In-depth intron junk DNA LTR Long Terminal Repeat In-depth mature peptide In-depth\ -mer mRNA messenger RNA mtDNA mitochondrial RNA non-coding regions nucleic acid nucleotide ORF Open Reading Frame oligo oligonucleotide open reading frame precursor RNA In-depth primary (initial, unprocessed)
transcript In-depth primary transcript In-depth promoter In-depth promoter regions in-depth protein coding protein coding sequence In-depth protein splicing In-depth rRNA ribosomal RNA in-depth RNA ribonucleic acid RNA splicing in-depth reading frame ribonucleic acid ribosomal RNA in-depth ribosomes in-depth scRNA small cytoplasmic RNA In-depth selfish DNA sequence sequence data, molecular In-depth signal peptide coding sequence In-depth snRNA small nuclear RNA splicing sticky ends In-depth tRNA In-depth template In-depth terminator In-depth transcription transfer RNA In-depth translation transit peptide coding sequence In-depth UTR untranslated region Sequencing glossary alignment assembled sequence BEAUTY In-depth BLAST Basic Local Alignment Search Tool BLAST2 In-depth chain termination method In-depth chemical cleavage sequencing In-depth chemical degradation sequencing In-depth consensus sequence conserved sequence contig contig assembly de novo sequencing In-depth dideoxy sequencing In-depth draft, working sequence, human FACS In-depth FASTA In-depth finished sequence, human finishing standards Human Genome Project flow cytometry In-depth flow sorting In-depth GRAIL Genome Recognition and Assembly
Internet Link software gap penalties gapped BLAST In-depth gaps genomic viewers global alignment local alignment Maxam-Gilbert sequencing In-depth microsequencing In-depth minisequencing In-depth multiple sequence alignment multiplex sequencing In-depth Needleman-Wunsch In-depth protein sets resequencing rough draft Sanger sequencing In-depth sequence alignments sequence analysis sequence homology, nucleic acid sequence similarity searches sequence tags In-depth sequencing high-throughput sequencing (proteins, nucleic acids) sequencing, high-throughput shotgun method shotgun sequencing Smith-Waterman alignment In-depth whole genome shotgun sequencing working draft, human sequence Structural genomics glossary ab initio modeling ab initio protein structure prediction CASP Critical Assessment of Technologies
for Protein Structure Alignment fold recognition granularity homology modeling NIGMS National Institute of General Medical
Sciences Protein Structure Factory Protein Structure Initiative protein structure prediction Structural Biology Industrial Platform structural genomics structure from sequence structure prediction problem threading Technologies & instrumentation overview applied molecular evolution atomic force microscopy AFM CE-MS Capillary Electrophoresis- Mass
Spectrometry combinatorial chemistry detector technologies disruptive technologies emerging technologies enabling technologies fluidics system gene shuffling genomics technologies - integrated hyphenated technologies I.R Thermography, infrared thermography integrated genomics technologies LC/MS Liquid Chromatography/ Mass Spectrometry mass spectrometry microarray microfabrication microtiter plate, microtitre plate miniaturization molecular evolution molecular motors multiplex NMR Nuclear Magnetic Resonance nanoparticles nonlinear PCR Polymerase Chain Reaction phage display robotic system robust sample preparation scanning technology semi-conductor synchrotrons X-ray crystallography. zeptomole This needs to be in a database, not word processing. I just can't
keep up with manual indexing. alpha gloss |