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MI-4速效抗抑郁药物动物实验表现良好

2014年5月6日讯 /生物谷BIOON/ --随着社会压力的与日俱增,世界各国抑郁症患者人数不断上升。仅在美国,每十个人中就有一个服用抗抑郁症药物。在上周举行的实验生物学2014年年会上,来自美国罗斯曼大学抗抑郁药物和药物成瘾研究中心的研究人员公布了一种名为MI-4的速效抗抑郁症药物动物实验结果。小鼠实验表明这种药物能够通过促进大脑的多巴胺、五羟色胺和去甲肾上腺素的分泌水平来迅速长效改善小鼠性情。而传统药物一般是针对这三种激素之一为靶点,这也解释了为什么一些抗抑郁药物对不同患者有不同药效。

这项研究的负责人Jeffery Talbot表示无论在起效时间还是药效持续时间上,MI-4都令人满意。同时,Jeffery Talbot还表示这种药物没有成瘾的危险。(生物谷Bioon.com)

详细英文报道:

A fast-acting antidepressant that provides a mood-lifting effect in mice within 24 hours and continues working for a sustained period may hold promise for use in humans.

For the more than one in 10 Americans taking antidepressants, fast-acting therapies would be preferable to those currently available, which can take weeks or months before alleviating symptoms. Antidepressants have proven themselves tricky for drug discovery and development because of the varying benefits the drugs provide to patients.

But a study presented at the Experimental Biology 2014 meeting last week of MI-4, also known as Ro-25-6981, backs up previous findings showing that the drug can cause a rapid antidepressant effect in animals by blocking a key signaling chemical in the brain. Previously, researchers were not aware of the full spectrum of MI-4's antidepressant properties.

Using standard tests designed to demonstrate antidepressant effects in rodents, the researchers found that MI-4 not only improves mood in mice with depression-like symptoms but works in the long term to provide sustained relief. It does this by using a three-pronged approach known as triple reuptake inhibition, which refers to a drug's ability to simultaneously increase the levels of dopamine, norepinephrine and serotonin, three chemicals in the brain associated with mood and feelings of pleasure. Most depression drugs target only one of these chemicals, which may explain the varied response among patients.

"What makes this study unique and exciting is that in the same drug we seem to have both of the properties you want in an antidepressant--both rapid and sustained effects," said study co-author Jeffery Talbot, director of the Research Center on Substance Abuse and Depression at Roseman University of Health Sciences in Nevada.

In addition, researchers concluded that it's unlikely that MI-4 would be addictive.

 

关键词:抗抑郁药物,五羟色胺,多巴胺,去甲肾上腺素

信息来源:生物谷