PNAS：土耳其禽流感幸存者带来的启示
研究禽流感幸存者的免疫系统可以为人类提供保护措施，预防当H5N1毒株发展出可在人与人之间的传播能力时可能出现的情形。
在美国《国家科学院院刊》（PNAS）的一篇论文中，Arun Kashyap所在的研究小组表示，除了传统的免疫接种措施外，使用经过幸存者免疫系统洗礼的防御分子、即抗体，也可以保护人体免受可能大流行的H5N1病毒的感染。研究人员利用2006年1月土耳其H5N1大爆发中的五位幸存者的骨髓样本建立了抗体库。这些抗体库包含了所有感染反应后出现的抗体，而且每个库中的抗体都仅来自于一个单独的个体。论文作者研究了300多个幸存者制造的明显抗体，他们发现有几个样本在实验室中可以中和H5N1病毒。研究人员称，除了制造被动免疫所用的抗体外，识别中和抗体间的共性也可以帮助指导设计有效的禽流感疫苗。（来源：Eurekalert！中文版）
生物谷推荐原始出处：
（PNAS），10.1073/pnas.0801367105，Arun K. Kashyap, Richard A. Lerner
Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies
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Abstract
The widespread incidence of H5N1 influenza viruses in bird populations poses risks to human health. Although the virus has not yet adapted for facile transmission between humans, it can cause severe disease and often death. Here we report the generation of combinatorial antibody libraries from the bone marrow of five survivors of the recent H5N1 avian influenza outbreak in Turkey. To date, these libraries have yielded >300 unique antibodies against H5N1 viral antigens. Among these antibodies, we have identified several broadly reactive neutralizing antibodies that could be used for passive immunization against H5N1 virus or as guides for vaccine design. The large number of antibodies obtained from these survivors provide a detailed immunochemical analysis of individual human solutions to virus neutralization in the setting of an actual virulent influenza outbreak. Remarkably, three of these antibodies neutralized both H1 and H5 subtype influenza viruses.
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