J Infect Dis ：抗利什曼病药物可促进人类细胞和组织HIV复制

生物谷

    加拿大研究者在1月15日的《传染病杂志》（J  Infect  Dis  2007;195:236-245.）上报告，被广泛使用的抗利什曼病药可促进人类细胞和组织HIV复制。

    研究负责人、Laval大学的Michel  J.  Tremblay博士说：“我们的数据显示，治疗利什曼病最常用的化合物，含锑药物葡萄糖酸锑钠，可促进CD4+  T细胞和淋巴样组织HIV-1复制，这些细胞和组织被认为是这种病原体的天然贮存场所。”

    Tremblay博士及其同事指出，这种药物是一种磷酸酪氨酰磷酸酶抑制剂，并且这种抑制剂可促进HIV-1复制。如上所述，研究组发现这种化合物确实可诱导初级CD4+  T细胞和胸腺组织HIV-1转录和病毒复制增加。
    Tremblay博士指出，利什曼病是HIV患者的重要机会性疾病，使用葡萄糖酸锑钠控制利什曼原虫和HIV-1双重感染患者的寄生虫血症应加以小心。

    他总结说，对这种双重感染患者，应该使用有效的抗寄生虫药物治疗，避免可能的利什曼原虫介导的HIV-1复制增加和随后的免疫学状态变差。

部分英文原文：

J Infect Dis. 2007 Jan 15;195 (2):236-45 17191169
HIV-1 Replication Is Stimulated by Sodium Stibogluconate, the Therapeutic Mainstay in the Treatment of Leishmaniasis.
[My paper] Corinne Barat , Chenqi Zhao , Marc Ouellette , Michel J Tremblay
Leishmaniasis is an important opportunistic disease among patients infected with human immunodeficiency virus (HIV)-1. The pentavalent antimony compound sodium stibogluconate is a drug of choice for the treatment of leishmaniasis. Because sodium stibogluconate acts as an inhibitor of phosphotyrosyl phosphatases and such inhibitors can promote HIV-1 replication, we tested the effect of this compound on virus gene expression. Using pseudotyped reporter viruses and fully infectious laboratory-adapted and clinical strains of HIV-1, we report that sodium stibogluconate induces an increase in HIV-1 transcription and virus replication in primary CD4(+) T cells and in thymic histocultures. This activation is a slow process and appears to involve the transcription factors nuclear factor- kappa B and activator protein 1, as well as the Syk, Jun, and mitogen-activated protein kinase/extracellular signal-related kinase signal-transduction pathways. In addition, the effect seems to be partly mediated by a soluble factor. Altogether, these findings might reveal clinical implications for the treatment of leishmaniasis in HIV-1-infected patients. 相关报道: 犬利什曼病的流行、诊断和防制德国开发出治疗利什曼病新药《Nature》：利什曼病的传播利什曼病(leishmaniasis cutaneous leishmaniasis)09 德国批准米替福新用于利什曼病利什曼病(leishmaniasis cutaneous leishmaniasis)11图片图谱印度批准米替福新用于利什曼病法国研制出防寄生虫病疫苗