生物谷报道：中科院上海神经科学研究所蒋辉博士一篇论文已被国际顶级刊物Cell接收，即将发表，这将是近多年来中国大陆第一篇正式的Cell论文（1980年王鏊全教授有一篇有关转座子的文章发表在cell上，后附摘要）。近年来Cell的影响因子有所下降，但是它的知名度和影响力仍然高居同类期刊之首。
蒋辉博士原是冯林音的学生，现在在神经所何士刚组，不过课题是由饶毅博士（Rao Yi）带的，但整个工作全部在中科院神经所内完成的，这篇文章的通讯作者是Rao Yi。应该是大陆的原产文章，是值得骄傲的。
但是神经所近年来Nature, science, Neuron, PNAS，Nature系列刊物上文章非常多，这与Poo MM先生在神经所的始建阶段建立了一套完善的学术体制和良好的学术氛围有关。可以说Poo先生是最大的背后功人。神经所一些高年级的学生毕业了，但这种氛围仍然保留了下来，神经所的学生很Active,很能提问题令我我觉得很重要的一点是神经所老板和学生的压力都很大，Poo push老板，老板push 学生，所以很多学生都做出了非常出色的工作。另据最新信息，神经所又有三篇Nature summit,其中两篇已经revise了，其中一篇是Nature 已经被接收为article。
神经所虽成立短短几年，但成果已在国内遥遥领先，已成为国内生物科学界第一块品牌，希望神经所在Poo先生带领下越走越远！
附1：
神经所近三年内已发表的重要文章[PDF文件全部可以下载]
Yu, W., Guo, W., and Feng, L. (2004) Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion. FEBS Lett. 577: 87-92. [PDF]
Yu, W., Guo, W., and Feng, L. (2004) Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion. FEBS Lett. 577: 87-92. [PDF]
Zhang, C., Xiong, W., Zheng, H., Wang, L., Lu, B., and Zhou, Z. (2004) Calcium- and Dynamin-Independent Endocytosis in Dorsal Root Ganglion Neurons. Neuron 42, 225-236. [ Abstract ] [ PDF ]
Xu, H., Yuan, X., Guan, C., Duan, S., Wu, C., and Feng, L. (2004) Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration. Proc. Natl. Acad. Sci. USA 101, 4296-4301. [ Abstract ] [ PDF ]
Li, C., Lu, J., Wu, J., Duan, S., and Poo, M. (2004) Bidirectional Modification of Presynaptic Neuronal Excitability Accompanying Spike Timing-Dependent Synaptic Plasticity. Neuron 41, 257-268. [ Abstract ] [ PDF ]
Yu, X., Duan, K., Shang, C., Yu, H., and Zhou, Z. (2004) Calcium Influx through Ih Channels Contributes to Activity-Evoked Neuronal Secretion. Proc. Natl. Acad. Sci. USA 101, 1051-1056. [ Abstract ] [ PDF ]
Duan, K., Yu, X., Zhang, C., and Zhou, Z. (2003) Control of Secretion by Temporal Patterns of Action Potentials in Adrenal Chromaffin Cells. J. Neurosci. 23, 11235-11243. [ Abstract ] [ PDF ]
Zhang, J., Wang, H., Ye, C., Ge, W., Chen, Y., Jiang, Z., Wu, C., Poo, M., and Duan, S. (2003) ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression. Neuron 40, 971-982. [ Abstract ] [ PDF ]
Yang, Y., Ge, W., Chen, Y., Zhang, Z., Shen, W., Wu, C., Poo, M., and Duan, S. (2003) Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proc. Natl. Acad. Sci. USA 100, 15194-15199. [ Abstract ] [ PDF ]
He, S., Dong, W., Deng, Q., Weng, S., and Sun, W. . (2003) Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry. (Review) Science 302, 408-41 [ Abstract ] [ PDF ]
Wang, Z., Xu, N., Wu, C., Duan, S., and Poo, M. (2003) Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications. Neuron 37, 463-472. [Abstract] [PDF]
Yuan, X., Jin, M., Xu, X., Song, Y., Wu, C., Poo M., and Duan, S. (2003)Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nature Cell Biol. 5, 38-45. [Abstract][PDF]
Xu, N., Bao, L., Fan, H., Bao, G., Pu, L., Lu, L., Wu, C., Zhang, X., and Pei, G.(2003) Morphine Withdrawal Increases Glutamate Uptake and Surface Expression of Glutamate Transporter GLT1 at Hippocampal Synapses. J. Neurosci. 23, 4775-4784. [Abstract ][PDF ]
Bao, L., Jin, S., Zhang, C., Wang, L., Xu, Z., Zhang, F., Wang, L., Ning, F., Cai, H., Guan, J., Xiao, H., Xu, Z., He, C., Hokfelt, T., Zhou, Z., and Zhang, X. (2003) Activation of delta-Opioid Receptors on Dorsal Root Ganglion Neurons Induces Receptor Insertion and Neuropeptide Secretion. Neuron 37, 121-133. [Abstract] [ PDF]
Yao, H., and Li, C. (2002) Clustered Organization of Neurons with Similar Extra-Receptive Field Properties in the Primary Visual Cortex. Neuron 35, 547-553. [Abstract][PDF]
Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X., Wu, C., Poo, M., and Duan, S. (2002) Nerve growth cone guidance mediated by G protein-coupled receptors. Nat. Neurosci. 5, 843-848. [Abstract][PDF]
Zhang, C., and Zhou, Z. (2002) Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons. Nat. Neurosci. 5, 425-430. [Abstract][PDF]
Xiao, H., Huang, Q., Zhang, F., Bao, L., Lu, Y., Guo, C., Yang, L., Huang, W., Fu, G., Xu, S., Cheng, X., Yan, Q., Zhu, Z., Zhang, X., Chen, Z., Han, Z., and Zhang, X. (2002) Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.Proc. Natl. Acad. Sci. USA 99, 8360-8365. [Abstract][PDF]
Tang, S., and Guo, A. (2001) Choice behavior of Drosophila facing contradictory visual cues. Science 294, 1543-1547. [ Abstract ] [ PDF ]
附2：
附3：神经所简介与Poo先生的简介
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Institute of Neuroscience |
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| An Introduction by Mu-ming Poo, Director | |||||||||||||||||||||||||||
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As part of a major drive for excellence in basic scientific research in the new millennium, the Chinese Academy of Sciences founded the Institute of Neuroscience (ION) on November 27, 1999. The institute is located on the campus of Shanghai Institutes for Biological Sciences and occupies a renovated building of Shanghai Brain Research Institute, an institute founded by Professor Chang Hsiang-Tung in 1980. The ION is devoted to research in all areas of basic neuroscience, including molecular and cellular neurobiology, developmental neurobiology, systems and behavioral neuroscience, and computational and cognitive neuroscience. At its inception, ION aims to instigate the infrastructure of a modern research institute that provides an environment for rigorous scientific pursuits and for fruitful interactions, a support and management system that facilitates major discoveries, a merit-based review system for promotion and funding, and high-quality education and training programs for the next generation of Chinese neuroscientists. An International Advisory Board consisting of a group of distinguished neuroscientists from abroad and the ION Council consisting of distinguished Chinese scientists are providing critical inputs into the evolving organization and research activities at ION. In December of 2003, an international team of scientists performed the first four-year scientific review of ION laboratories.
The ION presently consists of thirteen independent research laboratories: Laboratory of Cellular Biophysics, Laboratory of Neural Development, Laboratory of Neural Signal Transduction, Laboratory of Neural Plasticity, Laboratory of Synaptic Physiology, Laboratory of Synaptic Signaling, Laboratory of Synapse Development and Plasticity, Laboratory of Neurobiology of Diseases, Laboratory of Retinal Structure and Function, Laboratory of Sensory Systems, Laboratory of Learning and Memory, Laboratory of Vision and Cognition, and Laboratory of Visual Psychophysics. We are recruiting new laboratory heads at a rate of approximately two per year, with a goal of reaching a steady state of thirty laboratories by the year 2010. Each laboratory consists of up to five permanent staff members and a variable number of graduate students and postdoctoral fellows. Most laboratories have ongoing research collaborations with other research groups in China and abroad. Long-term collaborators are appointed as Guest Investigators of ION. The institute receives funding from Chinese Academy of Sciences, Ministry of Science and Technology, and Science and Technology Commission of Shanghai Municipality, that provides research support and facilities to our researchers at a level close to international standards. Research in neuroscience has been advancing at a rapid pace over the past few decades. The founding of ION in Shanghai provides a new opportunity for Chinese neuroscientists to flourish on their own soil and to contribute on a par with their counterparts on the international scene. Everyone who had visited Shanghai and ION recently would agree with me that the vitality and vibrancy of the place point to a bright future. Scientific contributions by ION researchers in the coming years are likely be as impressive, memorable, and long-lasting as those bronze vessels in the Shanghai Museum. 附4：神经所目前的主要实验室及PI简介[链接]
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附王敖全研究员文章，应该是国内有据可查的第一篇Cell
| Cell. 1980 Aug;21(1):251-5. |
The transposition properties of Tn2 in E. coli.
Wang A, Dai X, Lu D.
We report the characterization of Tn2 transpositions into the chromosome and into an F' lacproB episome of E. coli. When Tn2 transposes into the chromosome a proportion of the insertions result in auxotrophy. These insertions can revert to prototrophs and lose ampicillin resistance concomitantly. However, Tn2 insertions in F' lacproB are often associated with deletions, and it seems probable that insertion and deletion occur simultaneously.
