蛋白是差异性最大，应用最广泛的生物大分子，在所有生物过程中都扮演着关键的角色，目前科学家家们已经识别出了许多种细胞类型中的蛋白成分（蛋白质组学），他们冲上了蛋白科学研究中的前沿领域：从单个蛋白动力学的调控及功能研究发展为蛋白与蛋白相互作用的进化及限制。

    在本期的Nature杂志副刊上，以“Proteins to proteomes”为题，链接了一篇社论和五篇综述，都是免费下载，大家不要错过！

Proteins are the most diverse and versatile set of biological macromolecules, having crucial roles in all biological processes. Now that researchers have identified whole complements of proteins (proteomes) for many cell types, they are pushing the frontiers of protein science: from the regulation and function of single protein dynamics to the evolution and inhibition of protein–protein interactions.

Editorial
Proteins to proteomes（免费）
Tanguy Chouard & Joshua Finkelstein
doi:10.1038/450963a

Full Text | PDF (66KB)

Dynamic personalities of proteins free access

Katherine Henzler-Wildman & Dorothee Kern

doi:10.1038/nature06522

Abstract | Full Text | PDF (663KB)

The molecular sociology of the cell free access

Carol V. Robinson, Andrej Sali & Wolfgang Baumeister

doi:10.1038/nature06523

Abstract | Full Text | PDF (1,007KB)

The origin of protein interactions and allostery in colocalization free access

John Kuriyan & David Eisenberg

doi:10.1038/nature06524

Abstract | Full Text | PDF (867KB)

The biological impact of mass-spectrometry-based proteomics free access

Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III

doi:10.1038/nature06525

Abstract | Full Text | PDF (4,064KB)

Reaching for high-hanging fruit in drug discovery at protein–protein interfaces free access

James A. Wells & Christopher L. McClendon

doi:10.1038/nature06526

Abstract | Full Text | PDF (533KB) | Supplementary information