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8月23-24日Science & Nature内容精选

2007-8-27 17:32:00 信息来源: 生物谷 
  •   8月23-24日Science & Nature内容精选 8月23日《Nature》封面故事:细胞间隙连接处探秘间隙连接处是相邻细胞形成小孔或通道、让信号分子和离子在细胞之间自由通过的地方,它们存在于脊椎动物的很多成年细胞和正在发育的细胞中。它们的功能一直被认为在很大程度上是由于细胞之间的分子流动。但事情并不是这么简单。现在,Elias等人提供的证据表明,间隙连接处在神经迁移中发挥一定作用,而对迁移来说重要的是间隙连接蛋白的黏附性能及细胞之间接触点的性质,不是它们通道的导通性能。这一发现的意义已经超出了脑发育。因为很多其他间隙连接功能(包括参与肿瘤的转移)也可能取决于黏附性能而不是小孔功能,所以间隙连接处可能因以前没有被考虑到的方式而易于
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解释出体经历

利用虚拟现实的突眼镜将到达大脑的感觉信号混合起来,科学家在健康人身上诱发了类似出体经历(out-of-body-like experiences)的感受,这给一个通常被认为是一个想象的虚构的现象提出了一个科学解释。戴上突眼镜的人看到他们的身体位于别的位置,同时他们也能感到他们真正的身体受到触摸,这使得参加试验的志愿者感到身体移到了他们的物质躯体之外,本期一篇Henrik Ehrsson写的简报和一篇Bina Lenggenhager和同事的报告介绍了这项试验。研究人员说,大脑中处理这两类感觉信息回路之间的切断也许是某些出体经历的原因。

英文原文一:

Science 24 August 2007:
Vol. 317. no. 5841, p. 1048
DOI: 10.1126/science.1142175

The Experimental Induction of Out-of-Body Experiences

H. Henrik Ehrsson

I report an illusion in which individuals experience that they are located outside their physical bodies and looking at their bodies from this perspective. This demonstrates that the experience of being localized within the physical body can be determined by the visual perspective in conjunction with correlated multisensory information from the body.

Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK. Department of Clinical Neuroscience, Karolinska Institutet, 171 76 Stockholm, Sweden. E-mail: enrik.Ehrsson@ki.se   

英文原文二:

Science 24 August 2007:
Vol. 317. no. 5841, pp. 1096 - 1099
DOI: 10.1126/science.1143439

Video Ergo Sum: Manipulating Bodily Self-Consciousness

Bigna Lenggenhager,1 Tej Tadi,1 Thomas Metzinger,2,3 Olaf Blanke1,4*

Humans normally experience the conscious self as localized within their bodily borders. This spatial unity may break down in certain neurological conditions such as out-of-body experiences, leading to a striking disturbance of bodily self-consciousness. On the basis of these clinical data, we designed an experiment that uses conflicting visual-somatosensory input in virtual reality to disrupt the spatial unity between the self and the body. We found that during multisensory conflict, participants felt as if a virtual body seen in front of them was their own body and mislocalized themselves toward the virtual body, to a position outside their bodily borders. Our results indicate that spatial unity and bodily self-consciousness can be studied experimentally and are based on multisensory and cognitive processing of bodily information.

1 Laboratory of Cognitive Neuroscience, Ecole Polytechnique Fédérale de Lausanne, Station 15, 1015 Lausanne, Switzerland.
2 Philosophical Seminar, Johannes Gutenberg-Universität Mainz, 55099 Mainz, Germany.
3 Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe-Universität, 60438 Frankfurt am Main, Germany.
4 Department of Neurology, University Hospital, 1214 Geneva, Switzerland.

* To whom correspondence should be addressed. E-mail: olaf.blanke@epfl.ch

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