Prion在体内直接导致神经细胞凋亡

佚名

生物谷报道本周Science再发一篇有关Prion蛋白的报道,这是Prion研究中的新进展。有关它的报道在生物谷内有多篇。

Neuronal death is a prominent, but poorly understood, pathologicalhallmark of prion disease. Notably, in the absence of the cellularprion protein (PrP^C), the disease-associated isoform, PrP^Sc,appears not to be intrinsically neurotoxic, suggesting thatPrP^C itself may participate directly in the prion neurodegenerativecascade. Here, cross-linking PrP^C in vivo with specific monoclonalantibodies was found to trigger rapid and extensive apoptosisin hippocampal and cerebellar neurons. These findings suggestthat PrP^C functions in the control of neuronal survival andprovides a model to explore whether cross-linking of PrP^C byoligomeric PrP^Sc can promote neuronal loss during prion infection.

^{Original article:}

^{Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo}

Laura Solforosi, Jose R. Criado, Dorian B. McGavern, Sebastian Wirz, Manuel Sánchez-Alavez, Shuei Sugama, Lorraine A. DeGiorgio, Bruce T. Volpe, Erika Wiseman, Gil Abalos, Eliezer Masliah, Donald Gilden, Michael B. Oldstone, Bruno Conti, and R. Anthony Williamson
Science Mar 5 2004: 1514-1516. Published online January 29, 2004 [DOI: 10.1126/science.1094273] (in Science Express Reports ) [Abstract] [Full Text] [PDF] [Supporting Online Material]

^{Related article:}

^{Prion蛋白是神经细胞凋亡的关键}

^{Prion Pathway}