大脑是如何感知疼痛的机理被揭示
生物谷报道：今天刚刚出版的Science上刊登了2篇重要的文章，美国科学工作者研究大脑是如何感知道疼痛的。采用了fMRI等手段研究了大脑感知疼痛的脑区分布，作者采用安慰剂作为实验，实验设计和构思巧妙，有很强的说服力这是疼痛机理研究的最新进展。
The experience of pain arises from both physiological and psychological factors, including one's beliefs and expectations. Thus, placebo treatments that have no intrinsic pharmacological effects may produce analgesia by altering expectations. However, controversy exists regarding whether placebos alter sensory pain transmission, pain affect, or simply produce compliance with the suggestions of investigators. In two functional magnetic resonance imaging (fMRI) experiments, we found that placebo analgesia was related to decreased brain activity in pain-sensitive brain regions, including the thalamus, insula, and anterior cingulate cortex, and was associated with increased activity during anticipation of pain in the prefrontal cortex, providing evidence that placebos alter the experience of pain.
Original articles
- Empathy for Pain Involves the Affective but not Sensory Components of Pain
- Tania Singer, Ben Seymour, John O'Doherty, Holger Kaube, Raymond J. Dolan, and Chris D. Frith
Science 2004 303: 1157-1162. (in Research Articles)[Full Text] [PDF Version] - Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
- Tor D. Wager, James K. Rilling, Edward E. Smith, Alex Sokolik, Kenneth L. Casey, Richard J. Davidson, Stephen M. Kosslyn, Robert M. Rose, and Jonathan D. Cohen
Science 2004 303: 1162-1167. (in Research Articles)[Full Text] [PDF Version]
Comment:
Imaging Studies Show How Brain Thinks About Pain.Science Volume 303, Number 5661, Issue of 20 Feb 2004, p. 1121 [Full Text] [PDF Version]
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