AJMG：汞与儿童自闭症并无直接关联
生物谷援引华文生技网报道：近年来的诊断发现，儿童自闭症(Autism)增加的原因，可能与环境毒物有关，但是，美国密苏里大学哥伦比亚分校(University of Missouri-Columbia)的科学家却表示，为保存Rh免疫球蛋白(Rh immune globulin，简称RhIg)而使用的含汞抗菌剂，并不会提高孩童自闭症的风险。此研究由Judith Miles教授主导调查，发表于American Journal of Medical Genetics PartA的在线期刊，网址如下：http://www.interscience.wiley.com/ajmg。
虽然有些专家们认为自闭症的主因可能为基因问题所导致，并已有大量的研究指出这些含有汞抗菌剂的疫苗与自闭症无关，但仍有许多人继续在这个含有50% 乙基汞的抗菌剂上争论，而美国FDA、CDC以及AAP也建议将这些含汞的抗菌剂从儿童疫苗中移除，而此建议也于2002年达成。虽然美国国内已经不在儿童疫苗中含有汞成份的抗菌剂，但目前仍有许多国家仍使用含汞抗菌剂的疫苗。
此研究调查的对象包括214位母亲及230个被诊断有自闭症的孩童，观察他们的医疗记录，结果显示：这些自闭症的孩童中，他们的母亲为Rh阴性的情况并不显著，而这些孩童在出生前使用含汞RhIg的比例也不特别高。这项研究的调查数据显示含汞抗菌剂与儿童自闭症并无直接关联性。
（编译/陈瑞娟） (资料来源 : Bio.com)
英文原文链接：
原始出处：
Research Article
American Journal of Medical Genetics Part A，Published Online: 16 May 2007
Judith H. Miles *, T. Nicole Takahashi
Thompson Center for Autism and Neurodevelopmental Disorders, and Department of Child Health, University of Missouri Hospitals and Clinics, Columbia, Missouri
email: Judith H. Miles (milesjh@missouri.edu)
*Correspondence to Judith H. Miles, Department of Child Health, Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri Hospitals and Clinics, #1 Hospital Drive, Columbia, MO 65212.
How to cite this article: Miles JH, Takahashi TN. 2007. Lack of association between Rh status, Rh immune globulin in pregnancy and autism. Am J Med Genet Part A.
Funded by:
Johnson and Johnson Company Leda J. Sears Trust
| Keywords |
| autism ?Rh ?Rh immune globulin ?thimerosal ?RhoGam |
| Abstract |
| Though causes of autism are considered largely genetic, considerable concern remains that exposure to Rh immune globulin (RhIg), which until 2001 in the United States contained the preservative thimerosal, can cause autism. To determine whether mothers of children with autism are more likely to be Rh negative (Rh-) or to have received RhIg preserved with thimerosal, which is 49.6% ethyl mercury, we surveyed families of children with an autism spectrum disorder (ASD) ascertained through a University-based autism clinic considered free of ascertainment biases related to type of autism or severity. Between 2004 and 2006, 305 mothers of 321 children with an ASD agreed to participate in a telephone interview. Analysis of complete records including the blood group status and RhIg exposure of 214 families showed that Rh- status is no higher in mothers of children with autism than in the general population, exposure to antepartum RhIg, preserved with thimerosal is no higher for children with autism and pregnancies are no more likely to be Rh incompatible. This was also true for autism subgroups defined by behavioral phenotype, gender, IQ, regressive onset, head circumference, dysmorphology, birth status, essential, or complex phenotype. These findings support the consensus that exposure to ethylmercury in thimerosal is not the cause of the increased prevalence of autism. These data are important not only for parents in this country but also for the international health community where thimerosal continues to be used to preserve multi-dose vials which in turn makes vaccines affordable. © 2007 Wiley-Liss, Inc. |
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