Genes Dev：肿瘤抑制基因在胎盘发育过程中占有重要的作用

Education:

University of Calgary, Calgary, Canada 1988 B.S. Biochemistry
University of Calgary, Calgary, Canada 1994 Ph.D. Molecular Virology
Duke University Medical Center, Durham, N.C. 1998 Post-doc Genetics

Professional Experience:

1987-88 Undergraduate Research Assistant, Department of Microbiology and Infectious Diseases, University of Calgary
1988-94 Graduate Student, Department of Microbiology and Infectious Diseases, University of Calgary
1990-94 Graduate student assistant, University of Calgary, Project Lab (intensive laboratory training for undergraduates in virology and molecular biology)
1994-98 Postdoctoral Fellow, Department of Genetics, Duke University Medical Center (HHMI), Durham, North Carolina. Role of E2F in Cell Cycle Control
1999-present Assistant Professor, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Honors:

1989-94 Alberta Heritage Foundation for Medical Research Studentship
1994-97 Medical Research Council of Canada Fellowship and Alberta Heritage Foundation for Medical Research Fellowship
1997-99 Medical Research Council of Canada Centennial Fellowship
1999 The Robert M. and Barbara R. Bell Basic Science of Cancer Award
1999-01 The 1999 V - Foundation Scholar Award
2001-2005 The PEW Scholar Award
2004-2009 Scholar, Leukemia and Lymphoma Society

Representative Publications:

Sears, R., Leone, G., DeGregori, J., and Nevins,.J.R. (1999). Ras enhances Myc protein stability. Molecular Cell. 3:169-179.

Leone, G., DeGregori, J., Jakoi, L., Cook, J.G., and Nevins, J.R. (1999). Collaborative role of E2F transcriptional activity and G1 cyclin-dependent kinase activity in the induction of S phase. Proc. Natl. Acad. Sci. USA . 96:6626-6631.

Smith, DS., Leone, G., DeGregori, J., Ahmed, MN., Qumsiyeh, MB., Nevins, JR. (2000). Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Grow. & Diff. 11:625-633

Leone, G., Nuckolls, F., Ishida, S., Adams, M., Sears, R., Jakoi, L., Miron, A., Nevins, J.R. (2000) Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol. Cell. Biol. 20:10, 3626-3632

Adams,M.R., Sears, R., Nuckolls, F., Leone, G., and Nevins, J.R. (2000) Complex transcriptional regulatory mechanisms control expression of the E2F3 locus. Mol.Cell. Biol. 20:10 3633-3639.

Leone G., Sears R., Huang E., Rempel R., Nuckols F., Park C., Giangrande P., Wu L., Saavedra H.I., Field S.J., Thompson M.A., Yang H., Fujiwara Y., Greenberg M.E., Orkin S., Snith C., and Nevins J.R. (2001). Myc requires distinct E2F activities to induce S phase and apoptosis. Molecular Cell, 8: 105-113.

Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C. (2001). Transient ectopic expression of PTEN in thyroid can

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