对于一位科学家而言，能在同行评价审核的杂志上发表文章意味着专业同行高水平的评价，而如果这本杂志恰巧是《自然》或者《科学》这两个世界顶级的科学刊物之一的话更加说明了对这位科学家研究成果的肯定。来自佛罗里达州州立大学（Florida State University）分子生物物理学院（Institute of Molecular Biophysics）的李红就完成了一项得到双倍肯定的工作：在Nature和Science杂志同期发表论文。
在Science这篇文章中Li等人发现了一个Archaeglobus fulgidus的RNA剪接内切酶（RNA splicing endonuclease），为了解所谓的“生物分子”（即有机分子，包括蛋白质，核苷酸等）结构提出了新的观点见解。这项研究主要是利用了X射线结晶方法（X-ray crystallography）解析生物分子的三维结构，Li表示，“知晓生物分子的形状以及相关的化学性质是了解这些生物分子如何维持细胞生命活动的基础。这可以作个类比，人类心脏解剖研究可以帮助了解心脏的功能，同样对于生物分子的‘解剖’可以加深其功能的了解”。
而在另一篇文章中，Li和来自PTC Therapeutics（一家生物制药公司）的技术人员讨论了有关内含子结构剪接的相关发现：通过对真核tRNA-splicing endonuclease的分析，发现了一个以前从未发现的对于其催化作用有影响的活性位点。
这些发现可以帮助科学家们了解细胞中分子识别以及相互作用的基本化学与物理机理，FSU的Timothy Logan教授认为这项工作是为理解生物分子功能提供了重要信息，而且也为许多健康问题提出了新的治疗方案。
李红，毕业于四川大学，现为佛罗里达州州立大学assistant professor
Publicstion:
1. Xue, S., Calvin, K., and Li, H. “RNA Recognition and Cleavage by an RNA Splicing Endonuclease” Science (in press)
2. Trotta, C.R., Paushkin, S.V., Patel, M., Li, H. and Peltz, S.W. (2006) A composite active site for cleavage of pre-tRNA by the eukaryal tRNA splicing endonuclease. Nature (in press).
3. Rashid, R., Liang, B., Baker, D.L., Youssef, O.A., He, Y., Phipps, K., Terns, R. M., Terns, M., and Li, H. (2006) Crystal Structure of a Cbf5-Nop10-Gar1 complex and implication in RNA-guided pseudouridylation and dykeratosis congenita. Molecular Cell 21(2):249-260.
4. Randau, L., Calvin, K., Hall, M., Yuan, J., Podar, M., Li, H., and Soll, D. (2005) The heteromeric Nanoarchaeum equitans splicing endonuclease cleaves noncanonical bulge-helix-bulge motifs of joined tRNA halves. Proc. Natl. Acad. Sci. USA 102(50):17934-17939.
5. Calvin, K. Hall, M. Xu, F. and Xue, S., and Li, H. (2005) Structure and Function of an Ancient RNA Splicing Endonuclease with Broad Substrate Specificity. Journal of Molecular Biology 353(5):952-960.
6. Oruganti, S., Zhang, Y., and Li, H. (2005) Structural Comparison of Yeast snoRNP and SpliCEOsomal Protein Snu13p with Its Homologs. Biochemical and Biophysical Research Communication 333 (2): 550-554.
7. Aittaleb, M., Visone, T., Fenley, M. O., and Li, H. (2004) Structural and Thermodynamic Evidence for a Stabilizing Role of Nop5p in S-adenosyl-L-methionine Binding to Fibrillarin. Journal of Biological Chemistry 279 (40): 41822-41829.
8. Zhang, Y. and Li, H. (2004) Structure Determination of a Truncated Dimeric RNA Splicing Endonuclease in Pseudo-centered Space Group P21212. Acta Crystallographica Section D: Biological Crystallography D60, 447-452.
9. Moore, T., Zhang, Y., Fenley, M. O., and Li, H. (2004) Molecular Basis of Box C/D RNA-protein Interactions: Co-crystal Structure of the Archaeal sRNP Initiation Complex Structure 12(5): 807-18.
10. Aittaleb, M., Rashid, R., Chen, Q., Palmer, J. R., Daniels, C. J., and Li, H. (2003) Structure and function of archaeal box C/D sRNP core proteins Nature Structure Biology 10, 256-63.
11. Rashid, R., Aittaleb, M., Chen, Q., Spiegel, K., Demeler, B., and Li, H. (2003) Functional requirement for symmetric assembly of archaeal box C/D small ribonucleoprotein particles Journal of Molecular Biology 333, 295-306.
12. Lima, S., Hildenbrand, J., Korostelev, A., Hattman, S., and Li, H. (2002) Crystal structure of an RNA helix recognized by a zinc-finger protein: an 18-bp duplex at 1.6 Å resolution RNA 8, 924-32.
13. Story, R. M., Li, H., and Abelson, J. N. (2001) Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii Proceedings of the National Academy of Sciences U S A 98, 1465-70.
14. Li, H., and Abelson, J. (2000) Crystal structure of a dimeric archaeal splicing endonuclease J Mol Biol 302, 639-48.
15. Abelson, J., Trotta, C. R., and Li, H. (1998) tRNA splicing (minireview) Journal of Biological Chemistry 273, 12685-12688.
16. Li, H., Trotta, C. R., and Abelson, J. (1998) Crystal structure and evolution of a transfer RNA splicing enzyme Science 280, 279-284.
17. Li, H., Dunn, J. J., Luft, B. J., and Lawson, C. L. (1997) Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab Proceedings of the National Academy of Sciences U S A 94, 3584-3589.
18. Li, H., and Lawson, C. L. (1995) Crystallization and preliminary X-ray analysis of Borrelia burgdorferi outer surface protein A (OspA) complexed with a murine monoclonal antibody Fab fragment Journal of Structural Biology 115, 335-337.
19. Li, H., Hallows, W. H., Punzi, J. S., Pankiewicz, K. W., Watanabe, K. A., and Goldstein, B. M. (1994) Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes Biochemistry 33, 11734-11744.
20. Goldstein BM, Li H, Jones JP, Bell JE, Zeidler J, Pankiewicz KW, Watanabe KA. (1994) CNAD: a potent and specific inhibitor of alcohol dehydrogenase. Journal of Medicinal Chemistry 37, 392-399.
21. Goldstein, B. M., Li, H., Hallows, W. H., Langs, D. A., Franchetti P., Cappellacci, L., and Grifantini, M. (1994) C-glycosyl bond conformation in oxazofurin: crystallographic and computational studies of the oxazole analogue of tiazofurin Journal of Medicinal Chemistry 37, 1684-1688.
22. Li, H., Hallows, W. H., Punzi, J. S., Marquez, V. E., Carrell, H. L., Pankiewicz, K. W., Watanabe, K. A., and Goldstein, B. M. (1994) Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin Biochemistry 33, 23-32.
23. Li, H., Kennedy, S. D., and Goldstein, B. M. (1993) Solid-state and solution conformations of isotiazofurin: crystallographic, computational and 1H NMR studies Acta Crystallogrography B49, 729-738.
24. Li, H., and Goldstein, B. M. (1992) Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding Journal of Medicinal Chemistry 35, 3560-3567.
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