Science：细胞对环境的反应由神经元控制
专题：Science报道
生物谷报道：美国西北大学在Science发表了一项重大发现：多细胞动物中，单个细胞对环境的反应要听从神经元细胞的指挥。
以往人们一直认为，多细胞动物中每一个细胞都会独自应对外界刺激，好似一个单细胞生物。然而西北大学的科学家发现，线虫在感知温度时，单个细胞的“反应权”被移交给了两个专门感受温度的神经元，它俩会组织起整个机体的反应。也就是说，两个神经细胞控制了其他957个细胞的反应。
实验中，研究者通过基因手段阻断了上述两个神经元，使其不能感受温度，发现整个机体中再无细胞能够对温度变化作出反应。研究者检查其他957个细胞发现，单个细胞仍然可以感受到升温，然而由于神经元未发出信号，所以细胞无应有的反应。研究者认为，其他多细胞动物包括人类，也应有类似的组织反应的神经元。这一发现有助于加深对多细胞动物的理解。（生物谷www.bioon.com）
生物谷推荐原始出处：
Science，Vol. 320. no. 5877, pp. 811 - 814，Veena Prahlad，Richard I. Morimoto
Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons
Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.
Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
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