BMC Genomics：手机辐射能改变皮肤细胞蛋白质
生物谷报道：芬兰科研人员１２日发表的研究报告说，手机辐射能改变人体皮肤细胞中部分蛋白质，但他们尚不能确认这种改变对健康的影响。
这项研究报告说，芬兰“辐射和核安全局”工作人员把１０名女性志愿者前臂皮肤细胞在手机辐射中暴露１小时，而后对这些皮肤细胞进行了活组织检查。结果显示，与未暴露于辐射的对比皮肤细胞样本相比，这些皮肤细胞结构发生了改变。
报告说，研究人员分析实验用皮肤细胞中的５８０种蛋白质后，发现８种蛋白质受到手机辐射影响。
“手机辐射有某种生物效应，”“辐射和核安全局”研究人员达留什·莱斯金斯基说，“即使（细胞的）变化小，但它们确实存在。”
莱斯金斯基说，这项研究的目的只是求证人体活细胞是否对手机辐射有反应，并未发现手机辐射对健康的潜在危险。
“辐射和核安全局”称，上述研究在全球范围内首次揭示手机辐射造成的人体细胞分子层面变化。这一部门计划２００９年招募５０至１００名志愿者，展开规模更大的相关研究。
这项研究报告发表在互联网杂志《ＢＭＣ基因学》上。（生物谷援引新华社）
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BMC Genomics
Mobile phone radiation might alter protein expression in human skin
Anu Karinen 
, Sirpa Heinavaara , Reetta Nylund and Dariusz Leszczynski
BMC Genomics 2008, 9:77doi:10.1186/1471-2164-9-77
published: 11 February 2008
Abstract
Background
Earlier we have shown that the mobile phone radiation (radiofrequency modulated electromagnetic fields; RF-EMF) alters protein expression in human endothelial cell line. This does not mean that similar response will take place in human body exposed to this radiation. Therefore, in this pilot human volunteer study, using proteomics approach, we have examined whether a local exposure of human skin to RF-EMF will cause changes in protein expression in living people.
Results
Small area of forearm's skin in 10 female volunteers was exposed to RF-EMF (specific absorption rate SAR=1.3W/kg) and punch biopsies were collected from exposed and non exposed areas of skin. Proteins extracted from biopsies were separated using 2-DE and protein expression changes were analyzed using PDQuest software. Analysis has identified 8 proteins that were statistically significantly affected (Anova and Wilcoxon tests). Two of the proteins were present in all 10 volunteers. This suggests that protein expression in human skin might be affected by the exposure to RF-EMF. The number of affected proteins was similar to the number of affected proteins observed in our earlier in vitro studies.
Conclusions
This is the first study showing that molecular level changes might take place in human volunteers in response to exposure to RF-EMF. Our study confirms that proteomics screening approach can identify protein targets of RF-EMF in human volunteers.
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