肿瘤抑制因子PTEN抑制细胞迁移机理被揭示
生物谷报道：今天刚刚出版的Science报道了PTEN抑制细胞迁移的机制，它主要通过其C2结构域抑制捐资迁移，与对去IP3磷酸化无关，这可能是其抑制肿瘤的机制。
PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine383. The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.
Original article:
Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
Myrto Raftopoulou, Sandrine Etienne-Manneville, Annette Self, Sarah Nicholls, and Alan Hall
Science Feb 20 2004: 1179-1181.
- 众说风云 (已有0条评论)
