抗HIV药物可能增加"癌症风险"

生物谷

生物谷报道：最近，匹斯堡和美国的研究人员指出抗逆转录病毒的药物用于避免HIV从母体传染给孩子,这种药物可能引起婴儿基因损害,增加婴儿患癌症的风险.
两个新研究刊登在最新的环境与分子期刊上,报道在老鼠体内AZT(一种抗逆转录病毒的药物)经胎盘传递给胎儿有引起癌症的效应,并且发现肿瘤的生长速度增加了,也有癌症基因的改变,这些在人体癌症时常发生."虽然这些数据暗示人类儿童经胎盘被传递给了AZT的长期健康是不确定的,这些儿童在中老年时患癌症风险的增加这个可能性是高度值得相信的"根据研究人员报道."积累的遗传突变数据指出婴儿经胎盘被传递给了AZT,随着他们年龄的增长可能会提高患癌症的风险",研究者在陈述中指出.

原文出处：

Anti-HIV Drug May Increase 'Cancer Risk'

April 7, 2007 1:15 p.m. EST

Som Patidar - All Headline News Staff Writer
Pittsburgh, PA (AHN) - American scientists say antiretroviral drugs, which are used to prevent HIV transmission from mother to child, may cause genetic damage in infants that may increase their risk of developing cancer.

Two new studies published in the latest issue of Environment and Molecular Mutagenesis suggest that there are cancer-causing effects of transplacental exposure to AZT (an antiretroviral drug) in mice and rats and found increased rates of tumors and tumors with gene changes that frequently occur in human cancer.

"Although the implications of these findings for the long-term health of human children exposed transplacentally to AZT are uncertain, the possibility of increased cancer risk for a subset of these children in mid and late adulthood appears highly plausible," according to the researchers.

"The cumulative mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for cancer as they age," researchers said in a statement.