Genes&Dev：新型胰腺癌动物模型被建立

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Smads and Sp1." J. Biol. Chem, 27540014-40019, 2000.

Datta, P K, Blake, M C, Moses, H L Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1. J Biol Chem, 275(51), 40014-9, 2000.

Datta, P K, Moses, H L STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol, 20(9), 3157-67, 2000.

Datta, P.K. and Moses, H.L "STRAP and smad7 synergize in the inhibition of transforming growth factor-? signaling." Mol. Biol. Cell, 203157-3167, 2000.

Law, B.K., Waltner-Law, M.E., Entingh, A.J., Chytil, A., Aakre, M.E., N?rgaard, P., and Moses, H.L "Salicylate-induced growth arrest is associated with inhibition of p70s6k and downregulation of c- Myc, Cyclin D1, Cyclin A, and PCNA." J. Biol. Chem., 27538261-38267, 2000.

Law, B K, Waltner-Law, M E, Entingh, A J, Chytil, A, Aakre, M E, N??rgaard, P, Moses, H L Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J Biol Chem, 275(49), 38261-7, 2000.

N?rgaard, P., Law, B., Joseph, H., Page, D.L., Shyr, Y., Mays, D., Pietenpol, J.A., Kohl, N.E., Oliff, A., Coffey, R.J., Jr., Poulsen, H.S., and Moses, H.L "Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in TGF-a and TGF-a/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis." Clin. Cancer Res., 535-42, 1999.

N??rgaard, P, Law, B K, Plovisson, H S, Moses, H L Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation. Ann N Y Acad Sci, 886265-8, 1999.

Law, B K, N??rgaard, P, Gnudi, L, Kahn, B B, Poulson, H S, Moses, H L Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J Biol Chem, 274(8), 4743-8, 1999.

Law, B.K., N?rgaard, P., Gudi, L., Kahn, B.B., Poulson, H.S. and Moses, H.L "Inhibition of Dna synthesis by a farnesyltransferase inhibitor involves inhibition of the p70s6k pathway." J. Biol. Chem., 2744743-4748, 1999.

Engel, M.E., McDonnell, M.A., Law, B.K. and Moses, H.L "Interdependent SMAD and JNK signaling in transforming growth factor-?- mediated transcription." J. Biol. Chem. , 27437413-37420, 1999.

Engel, M E, McDonnell, M A, Law, B K, Moses, H L Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem, 274(52), 37413-20, 1999.

Joseph, H, Gorska, A E, Sohn, P, Moses, H L, Serra, R Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. Mol Biol Cell, 10(4), 1221-34, 1999.

Joseph, H., Gorska, A.E., Sohn, P., Moses, H.L., and Serra, R "Overexpression of a kniase deficient TGF-? type II receptor in mouse mammary stroma results in increased epithelial branching." Mol. Biol. Cell., 101221-1234, 1999.

Saha, D., Datta, P.K., Sheng, H., Morrow, J.D., Wada, M., Moses, H.L., and Beauchamp, R.D "Synergistic Induction of Cyclooxygenase-2 by Transforming Growth Factor-b1 and Epidermal Growth Factor Inhibits Apoptosis in Epithelial Cells." Neoplasia, 1508-517, 1999.

Saha, D, Datta, P K, Sheng, H, Morrow, J D, Wada, M, Moses, H L, Beauchamp, R D Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia, 1(6), 508-17, 1999.

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