Cancer Res：维生素D加止痛药能够抑制前列腺癌
近期发表在《癌症研究》杂志上的文章称，低剂量维生素D和止痛药按一定比例制成的混合物可有效抑制引发前列腺癌的癌细胞。
之前美国哈佛医学院的研究人员发现，维生素D中一种叫做“活性维生素D3（Calcitriol）”能够抑制前列腺癌癌细胞的生长。通过进一步研究，研究人员发现，“活性维生素D3（Calcitriol）”和止痛药按一定比例制成的混合物能够对前列癌癌细胞的生长有效抑制70%，而单独使用“活性维生素D3”只能抑制25%的癌细胞。
据悉，全球约有50%的男性患有前列腺疾病，包括前列腺炎与前列腺癌。在美国，前列腺癌是男性易患的第二大类癌症，仅次于肺癌，大约每5个美国男性就有一人患前列腺癌。
原文出处：
Moreno J, Krishnan AV, Swami S, Nonn L, Peehl DM, Feldman D. Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Res. 2005 Sep 1;65(17):7917-25.
Professor David Feldman and his colleagues from the Stanford University School of Medicine have reported the results of their study in the journal Cancer Research. The result of the study has found that high doses of Vitamin D with pain killers were found to reduce the growth of cancer in patients with prostate cancer. The study result say that the combination of these two drugs reduces the growth of prostate cancer by 70 percent.
Due to very impressive results, the research team has started a clinical trial to see if the approach also works in men. "There is great enhancement when the drugs are given together, using what we think is a safe dose in humans," Feldman said in a statement. "It‘s hard to make an exact comparison, as we are talking about cells in a dish and not a person." "We don‘t want the patient to think that if they take over-the-counter vitamin D, it will work in the same way," Feldman said.
The research team is testing the effect of Calcitriol, which is a form of Vitamin D that is efficiently metabolized by the body and more effective than other Vitamin D pills and fortified milk. The researchers wanted to exploit the earlier research results of Calcitriol and pain killers in the treatment of cancer, the workers wanted to test the synergistic effect of combining both the drugs for cancer treatment.
In a tissue culture study involving tumor cells, the administration of calcitriol reduced the prostate cell growth by 25 percent and combining painkillers like ibuprofen and naproxen with calcitriol killed 70 percent of the prostate cancer cells.
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